Synthesis of medium-ring lactams and macrocyclic peptide mimetics via conjugate addition/ring expansion cascade reactions

A novel conjugate addition/ring expansion (CARE) cascade reaction sequence is reported that enables medium-sized ring and macrocyclic bis-lactams to be prepared from primary amines and cyclic imides. The reactions are simple to perform, generally high yielding, and very broad in scope, especially wi...

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Detalles Bibliográficos
Autores principales: Palate, Kleopas Y., Yang, Zhongzhen, Whitwood, Adrian C., Unsworth, William P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905531/
https://www.ncbi.nlm.nih.gov/pubmed/35359493
http://dx.doi.org/10.1039/d1cb00245g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905531/
https://www.ncbi.nlm.nih.gov/pubmed/35359493
http://dx.doi.org/10.1039/d1cb00245g

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