In-Silico and In-Vitro Analysis of Human SOS1 Protein Causing Noonan Syndrome - A Novel Approach to Explore the Molecular Pathways

AIMS: Perform in-silico analysis of human SOS1 mutations to elucidate their pathogenic role in Noonan syndrome (NS). BACKGROUND: NS is an autosomal dominant genetic disorder caused by single nucleotide mutation in PTPN11, SOS1, RAF1, and KRAS genes. NS is thought to affect approximately 1 in 1000. N...

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Detalles Bibliográficos
Autores principales: Sigamani, Vinoth, Rajasingh, Sheeja, Gurusamy, Narasimman, Panda, Arunima, Rajasingh, Johnson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905634/
https://www.ncbi.nlm.nih.gov/pubmed/35386434
http://dx.doi.org/10.2174/1389202922666211130144221

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