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Rectal roflumilast improves trinitrobenzenesulfonic acid-induced chronic colitis in rats

Roflumilast, a highly selective oral phosphodiesterase IV inhibitor, exerts anti-inflammatory and anti-fibrotic effects. Oral roflumilast causes gastrointestinal side effects, especially vomiting, which could be reduced by administering roflumilast via off-label routes. Inhaled roflumilast reportedl...

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Detalles Bibliográficos
Autores principales:	Shaikh-Omar, A., Murad, H.A., Alotaibi, N.M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Associação Brasileira de Divulgação Científica 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905672/ https://www.ncbi.nlm.nih.gov/pubmed/35239781 http://dx.doi.org/10.1590/1414-431X2021e11877

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