Sickle cell disease promotes sex-dependent pathological bone loss through enhanced cathepsin proteolytic activity in mice

Sickle cell disease (SCD) is the most common hereditary blood disorder in the United States. SCD is frequently associated with osteonecrosis, osteoporosis, osteopenia, and other bone-related complications such as vaso-occlusive pain, ischemic damage, osteomyelitis, and bone marrow hyperplasia known...

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Detalles Bibliográficos
Autores principales: Selma, Jada, Song, Hannah, Rivera, Christian, Douglas, Simone, Akella, Abhiramgopal, Bollavaram, Keval, Thompson, Nishone, Platt, Manu O., Botchwey, Edward A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Red Cells, Iron, and Erythropoiesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905708/
https://www.ncbi.nlm.nih.gov/pubmed/34547771
http://dx.doi.org/10.1182/bloodadvances.2021004615

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