Mechanistic insights into the C(55)-P targeting lipopeptide antibiotics revealed by structure–activity studies and high-resolution crystal structures

The continued rise of antibiotic resistance is a global concern that threatens to undermine many aspects of modern medical practice. Key to addressing this threat is the discovery and development of new antibiotics that operate by unexploited modes of action. The so-called calcium-dependent lipopept...

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Detalles Bibliográficos
Autores principales: Wood, Thomas M., Zeronian, Matthieu R., Buijs, Ned, Bertheussen, Kristine, Abedian, Hanieh K., Johnson, Aidan V., Pearce, Nicholas M., Lutz, Martin, Kemmink, Johan, Seirsma, Tjalling, Hamoen, Leendert W., Janssen, Bert J. C., Martin, Nathaniel I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905900/
https://www.ncbi.nlm.nih.gov/pubmed/35382464
http://dx.doi.org/10.1039/d1sc07190d

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