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COVID-19 encephalopathy: an unusual presentation with new-onset seizure causing convulsive status epilepticus

Although neurological manifestations such as headache and myalgias have been observed with COVID-19, presentation with more serious neurological illness is uncommon and rare. We report a case of a middle-aged woman who presented to the emergency department of a tertiary care hospital. Her clinical p...

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Autores principales: Siddiqui, Aisha Fareed, Saadia, Sheema, Ejaz, Taymmia, Mushtaq, Zain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905954/
https://www.ncbi.nlm.nih.gov/pubmed/35260396
http://dx.doi.org/10.1136/bcr-2021-245387
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author Siddiqui, Aisha Fareed
Saadia, Sheema
Ejaz, Taymmia
Mushtaq, Zain
author_facet Siddiqui, Aisha Fareed
Saadia, Sheema
Ejaz, Taymmia
Mushtaq, Zain
author_sort Siddiqui, Aisha Fareed
collection PubMed
description Although neurological manifestations such as headache and myalgias have been observed with COVID-19, presentation with more serious neurological illness is uncommon and rare. We report a case of a middle-aged woman who presented to the emergency department of a tertiary care hospital. Her clinical presentation was primarily neurological rather than the more common presentation with respiratory manifestations. She presented with generalised tonic–clonic seizures, along with history of undocumented low-grade fever and generalised body aches. The positive SARS-CoV-2 RT-PCR nasal swab, the cerebrospinal fluid analysis (lymphocytic pleocytosis) and electroencephalogram were consistent with viral encephalitis; brain imaging was unremarkable. This case highlights the variable presenting features of COVID-19 infection as patients can primarily present with neurological manifestations in the absence of significant respiratory symptoms. We believe it is important to recognise neurological disease associated with SARS-CoV-2 in patients with asymptomatic respiratory infection.
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spelling pubmed-89059542022-03-25 COVID-19 encephalopathy: an unusual presentation with new-onset seizure causing convulsive status epilepticus Siddiqui, Aisha Fareed Saadia, Sheema Ejaz, Taymmia Mushtaq, Zain BMJ Case Rep Case Reports: Unusual association of diseases/symptoms Although neurological manifestations such as headache and myalgias have been observed with COVID-19, presentation with more serious neurological illness is uncommon and rare. We report a case of a middle-aged woman who presented to the emergency department of a tertiary care hospital. Her clinical presentation was primarily neurological rather than the more common presentation with respiratory manifestations. She presented with generalised tonic–clonic seizures, along with history of undocumented low-grade fever and generalised body aches. The positive SARS-CoV-2 RT-PCR nasal swab, the cerebrospinal fluid analysis (lymphocytic pleocytosis) and electroencephalogram were consistent with viral encephalitis; brain imaging was unremarkable. This case highlights the variable presenting features of COVID-19 infection as patients can primarily present with neurological manifestations in the absence of significant respiratory symptoms. We believe it is important to recognise neurological disease associated with SARS-CoV-2 in patients with asymptomatic respiratory infection. BMJ Publishing Group 2022-03-08 /pmc/articles/PMC8905954/ /pubmed/35260396 http://dx.doi.org/10.1136/bcr-2021-245387 Text en © BMJ Publishing Group Limited 2022. No commercial re-use. See rights and permissions. Published by BMJ.
spellingShingle Case Reports: Unusual association of diseases/symptoms
Siddiqui, Aisha Fareed
Saadia, Sheema
Ejaz, Taymmia
Mushtaq, Zain
COVID-19 encephalopathy: an unusual presentation with new-onset seizure causing convulsive status epilepticus
title COVID-19 encephalopathy: an unusual presentation with new-onset seizure causing convulsive status epilepticus
title_full COVID-19 encephalopathy: an unusual presentation with new-onset seizure causing convulsive status epilepticus
title_fullStr COVID-19 encephalopathy: an unusual presentation with new-onset seizure causing convulsive status epilepticus
title_full_unstemmed COVID-19 encephalopathy: an unusual presentation with new-onset seizure causing convulsive status epilepticus
title_short COVID-19 encephalopathy: an unusual presentation with new-onset seizure causing convulsive status epilepticus
title_sort covid-19 encephalopathy: an unusual presentation with new-onset seizure causing convulsive status epilepticus
topic Case Reports: Unusual association of diseases/symptoms
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905954/
https://www.ncbi.nlm.nih.gov/pubmed/35260396
http://dx.doi.org/10.1136/bcr-2021-245387
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