Selective covalent targeting of SARS-CoV-2 main protease by enantiopure chlorofluoroacetamide

The coronavirus disease 2019 (COVID-19) pandemic has necessitated the development of antiviral agents against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The main protease (M(pro)) is a promising target for COVID-19 treatment. Here, we report an irreversible SARS-CoV-2 M(pro) inhib...

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Detalles Bibliográficos
Autores principales: Yamane, Daiki, Onitsuka, Satsuki, Re, Suyong, Isogai, Hikaru, Hamada, Rui, Hiramoto, Tadanari, Kawanishi, Eiji, Mizuguchi, Kenji, Shindo, Naoya, Ojida, Akio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8905997/
https://www.ncbi.nlm.nih.gov/pubmed/35432850
http://dx.doi.org/10.1039/d1sc06596c

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