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Overcoming peri- and ortho-selectivity in C–H methylation of 1-naphthaldehydes by a tunable transient ligand strategy

Methyl groups widely exist in bioactive molecules, and site-specific methylation has become a valuable strategy for their structural functionalization. Aiming to introduce this smallest alkyl handle, a highly regioselective peri- and ortho-C–H methylation of 1-naphthaldehyde by using a transient lig...

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Detalles Bibliográficos
Autores principales: Mao, Yujian, Jiang, Jing, Yuan, Dandan, Chen, Xiuzhen, Wang, Yanan, Hu, Lihong, Zhang, Yinan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906006/
https://www.ncbi.nlm.nih.gov/pubmed/35382469
http://dx.doi.org/10.1039/d1sc05899a