A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors

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Effective drugs against SARS-CoV-2 are urgently needed to treat severe cases of infection and for prophylactic use. The main viral protease (nsp5 or 3CLpro) represents an attractive and possibly broad-spectrum target for drug development as it is essential to the virus life cycle and highly conserve...

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Detalles Bibliográficos
Autores principales: Chen, K.Y., Krischuns, T., Varga, L. Ortega, Harigua-Souiai, E., Paisant, S., Zettor, A., Chiaravalli, J., Delpal, A., Courtney, D., O'Brien, A., Baker, S.C., Decroly, E., Isel, C., Agou, F., Jacob, Y., Blondel, A., Naffakh, N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906008/
https://www.ncbi.nlm.nih.gov/pubmed/35278581
http://dx.doi.org/10.1016/j.antiviral.2022.105272
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