Considerations for anthelmintic resistance emergence in hookworm at a single locus

Over 800 million people are infected with hookworms around the world. Hookworms of the genus Ancylostoma and Necator are examples of nematodes that harbor the ability to enter a host by penetrating the skin, and after entry the infective larvae migrate to the small intestine where they encounter host-specific signals that initiate developmental pathways and culminate in maturation to the adult stage. Currently no vaccine is available for the treatment of hookworm infection. The control strategy is limited to anthelmintic drugs, which run the risk of losing efficacy as resistance grows. Genetic resistance has developed against all classes of anthelmintic drugs against livestock parasites, and recently markers of anthelmintic resistance in human hookworm populations have been reported. As anthelmintic resistance develops in human populations of hookworm, new drugs and novel control methods like vaccines will be required in the future to control hookworm transmission. This review outlines how population genetics and anthelmintic resistance could interact at a single locus to influence current control strategies.