Cargando…

Monobodies with potent neutralizing activity against SARS-CoV-2 Delta and other variants of concern

Neutralizing antibodies against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are useful for patients’ treatment of the coronavirus disease 2019 (COVID-19). We report here affinity maturation of monobodies against the SARS-CoV-2 spike protein and their neutralizing activity agains...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kondo, Taishi, Matsuoka, Kazuhiro, Umemoto, Shun, Fujino, Tomoshige, Hayashi, Gosuke, Iwatani, Yasumasa, Murakami, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906176/ https://www.ncbi.nlm.nih.gov/pubmed/35256514 http://dx.doi.org/10.26508/lsa.202101322

Ejemplares similares

Large-scale analysis of mRNA sequences localized near the start and amber codons and their impact on the diversity of mRNA display libraries
por: Umemoto, Shun, et al.
Publicado: (2023)

Antibody-like proteins that capture and neutralize SARS-CoV-2
por: Kondo, T., et al.
Publicado: (2020)

Monobodies and other synthetic binding proteins for expanding protein science
por: Sha, Fern, et al.
Publicado: (2017)

A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain
por: Wojcik, John, et al.
Publicado: (2010)

Mutational and biophysical robustness in a prestabilized monobody
por: Chandler, Peter G., et al.
Publicado: (2021)

Facile target validation in an animal model with intracellularly expressed monobodies
por: Gupta, Ankit, et al.
Publicado: (2018)

Monobodies as possible next-generation protein therapeutics – a perspective
por: Oliver, Hantschel
Publicado: (2017)

Development and Differentiation in Monobodies Based on the Fibronectin Type 3 Domain
por: Chandler, Peter G., et al.
Publicado: (2020)

Proof of dual-topology architecture of Fluc F(-) channels with monobody blockers
por: Stockbridge, Randy B., et al.
Publicado: (2014)

Development of light-responsive protein binding in the monobody non-immunoglobulin scaffold
por: Carrasco-López, César, et al.
Publicado: (2020)

Monobodies as tool biologics for accelerating target validation and druggable site discovery
por: Akkapeddi, Padma, et al.
Publicado: (2021)

Potent Neutralization of Omicron and other SARS-CoV-2 Variants of Concern by Biparatopic Human VH Domains
por: Chen, Chuan, et al.
Publicado: (2022)

Among Antibody-Like Molecules, Monobodies, Able to Interact with Nucleocapsid Protein of SARS-CoV Virus, There Are Monobodies with High Affinity to Nucleocapsid Protein of SARS-CoV-2 Virus
por: Khramtsov, Y. V., et al.
Publicado: (2022)

Delta breakthrough infections elicit potent, broad and durable neutralizing antibody responses
por: Walls, Alexandra C., et al.
Publicado: (2021)

Engineering of monobody conjugates for human EphA2-specific optical imaging
por: Kim, Min-A, et al.
Publicado: (2017)

Engineering Calreticulin-Targeting Monobodies to Detect Immunogenic Cell Death in Cancer Chemotherapy
por: Zhang, Ying, et al.
Publicado: (2021)

Tuning SAS-6 architecture with monobodies impairs distinct steps of centriole assembly
por: Hatzopoulos, Georgios N., et al.
Publicado: (2021)

Monobody adapter for functional antibody display on nanoparticles for adaptable targeted delivery applications
por: Albert, C., et al.
Publicado: (2022)

Structures of a FtsZ single protofilament and a double-helical tube in complex with a monobody
por: Fujita, Junso, et al.
Publicado: (2023)

A Bispecific Antibody Targeting RBD and S2 Potently Neutralizes SARS-CoV-2 Omicron and Other Variants of Concern
por: Yuan, Mengqi, et al.
Publicado: (2022)

Characterization of Monobody Scaffold Interactions with Ligand via Force Spectroscopy and Steered Molecular Dynamics
por: Cheung, Luthur Siu-Lun, et al.
Publicado: (2015)

Mechanism of single- and double-sided inhibition of dual topology fluoride channels by synthetic monobodies
por: Turman, Daniel L., et al.
Publicado: (2017)

Targeted Protein Degradation through Cytosolic Delivery of Monobody Binders Using Bacterial Toxins
por: Schmit, Nadine Eliane, et al.
Publicado: (2019)

mRNA vaccines elicit potent neutralization against multiple SARS-CoV-2 omicron subvariants and other variants of concern
por: Wang, Gang, et al.
Publicado: (2022)

Neutralizing activity of BBIBP-CorV vaccine-elicited sera against Beta, Delta and other SARS-CoV-2 variants of concern
por: Yu, Xiaoqi, et al.
Publicado: (2022)

Selective Targeting of SH2 Domain–Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies
por: Kükenshöner, Tim, et al.
Publicado: (2017)

Potent monoclonal antibodies neutralize Omicron sublineages and other SARS-CoV-2 variants
por: Chen, Zhaochun, et al.
Publicado: (2022)

Evaluation of the Neutralizing Antibody STE90-C11 against SARS-CoV-2 Delta Infection and Its Recognition of Other Variants of Concerns
por: Abassi, Leila, et al.
Publicado: (2023)

Broad and potent neutralizing antibodies are elicited in vaccinated individuals following Delta/BA.1 breakthrough infection
por: Seow, Jeffrey, et al.
Publicado: (2023)

Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains
por: La Sala, Grégory, et al.
Publicado: (2020)

Exploring switch II pocket conformation of KRAS(G12D) with mutant-selective monobody inhibitors
por: Akkapeddi, Padma, et al.
Publicado: (2023)

Genomic Analysis of SARS-CoV-2 Alpha, Beta and Delta Variants of Concern Uncovers Signatures of Neutral and Non-Neutral Evolution
por: Kurpas, Monika Klara, et al.
Publicado: (2022)

Isolation and Characterization of a Monobody with a Fibronectin Domain III Scaffold That Specifically Binds EphA2
por: Park, Seung-Hwan, et al.
Publicado: (2015)

FN3-based monobodies selective for the receptor binding domain of the SARS-CoV-2 spike protein
por: Miller, Christina J., et al.
Publicado: (2021)

Inhibition of RAS-driven signaling and tumorigenesis with a pan-RAS monobody targeting the Switch I/II pocket
por: Wallon, Lauren, et al.
Publicado: (2022)

A Booster Dose of CoronaVac Increases Neutralizing Antibodies and T Cells that Recognize Delta and Omicron Variants of Concern
por: Schultz, Bárbara M., et al.
Publicado: (2022)

Analysis of Vaccine Effectiveness Against COVID-19 and the Emergence of Delta and Other Variants of Concern in Utah
por: Keegan, Lindsay T., et al.
Publicado: (2021)

Directed Evolution of a Highly Specific FN3 Monobody to the SH3 Domain of Human Lyn Tyrosine Kinase
por: Huang, Renhua, et al.
Publicado: (2016)

Design and Evaluation of Engineered Extracellular Vesicle (EV)-Based Targeting for EGFR-Overexpressing Tumor Cells Using Monobody Display
por: Komuro, Hiroaki, et al.
Publicado: (2022)

Quasispecies Analyses of the HIV-1 Near-full-length Genome With Illumina MiSeq
por: Ode, Hirotaka, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_056n1pqa1laeu46prl6j0b9ugq