Cargando…

TCR-independent Activation in Presence of a Src-family Kinase Inhibitor Improves CAR-T Cell Product Attributes

Chimeric antigen receptor expressing T cells (CAR-T cells) have shown remarkable efficacy against some blood cancers and have potential to treat many other human diseases. During CAR-T cell manufacturing, T cells are activated via engagement of the T-cell receptor (TCR); however, persistent TCR enga...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lamture, Gauri, Baer, Alan, Fischer, Joseph W., Colon-Moran, Winston, Bhattarai, Nirjal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2022
Materias:	Basic Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906249/ https://www.ncbi.nlm.nih.gov/pubmed/34802014 http://dx.doi.org/10.1097/CJI.0000000000000402

Ejemplares similares

Src-family kinases negatively regulate NFAT signaling in resting human T cells
por: Baer, Alan, et al.
Publicado: (2017)

A short hepatitis C virus NS5A peptide expression by AAV vector modulates human T cell activation and reduces vector immunogenicity
por: Colon-Moran, Winston, et al.
Publicado: (2021)

Characterization of the effects of immunomodulatory drug fingolimod (FTY720) on human T cell receptor signaling pathways
por: Baer, Alan, et al.
Publicado: (2018)

CAR-T Cell Therapy: Mechanism, Management, and Mitigation of Inflammatory Toxicities
por: Fischer, Joseph W., et al.
Publicado: (2021)

TCR-like CARs and TCR-CARs targeting neoepitopes: an emerging potential
por: Poorebrahim, Mansour, et al.
Publicado: (2021)

Hepatitis C virus infection inhibits a Src-kinase regulatory phosphatase and reduces T cell activation in vivo
por: Bhattarai, Nirjal, et al.
Publicado: (2017)

Joining Forces for Cancer Treatment: From “TCR versus CAR” to “TCR and CAR”
por: Teppert, Karin, et al.
Publicado: (2022)

Roles of the Src Tyrosine Kinases Lck and Fyn in Regulating γδTCR Signal Strength
por: Laird, Renee M., et al.
Publicado: (2010)

The Enigmatic Nature of the TCR-pMHC Interaction: Implications for CAR-T and TCR-T Engineering
por: Shevyrev, D. V., et al.
Publicado: (2022)

CAR NK-92 cell–mediated depletion of residual TCR(+) cells for ultrapure allogeneic TCR-deleted CAR T-cell products
por: Kath, Jonas, et al.
Publicado: (2023)

C-terminal Src kinase (Csk) regulates the tricellular junction protein Gliotactin independent of Src
por: Samarasekera, G. D. N. Gayathri, et al.
Publicado: (2018)

2064: Deconstructing the peptide specificity of TCR recognition
por: Riley, Timothy P., et al.
Publicado: (2018)

Enhancing Efficacy of TCR-engineered CD4(+) T Cells Via Coexpression of CD8α
por: Anderson, Victoria E., et al.
Publicado: (2023)

Src-like adaptor protein down-regulates T cell receptor (TCR)–CD3 expression by targeting TCRζ for degradation
por: Myers, Margaret D., et al.
Publicado: (2005)

Challenges of CAR- and TCR-T cell–based therapy for chronic infections
por: Bertoletti, Antonio, et al.
Publicado: (2020)

A Costimulatory CAR Improves TCR-based Cancer Immunotherapy
por: Omer, Bilal, et al.
Publicado: (2022)

Tracking the CAR-T Revolution: Analysis of Clinical Trials of CAR-T and TCR-T Therapies for the Treatment of Cancer (1997–2020)
por: Ivica, Nikola A., et al.
Publicado: (2021)

Conserved Motifs within Hepatitis C Virus Envelope (E2) RNA and Protein Independently Inhibit T Cell Activation
por: Bhattarai, Nirjal, et al.
Publicado: (2015)

Tyrosine kinase signaling-independent MET-targeting with CAR-T cells
por: Qin, Anna, et al.
Publicado: (2023)

Potent, Selective CARs as Potential T-Cell Therapeutics for HPV-positive Cancers
por: Wang, Xueyin, et al.
Publicado: (2021)

89723 CD105-targeted CAR T cells for the treatment of acute myeloid leukemia
por: Lontos, Konstantinos, et al.
Publicado: (2021)

CAR-J cells for antibody discovery and lead optimization of TCR-like immunoglobulins
por: Jost, Christian, et al.
Publicado: (2020)

TCR-Like CAR-T Cells Targeting MHC-Bound Minor Histocompatibility Antigens
por: Akatsuka, Yoshiki
Publicado: (2020)

Current and future concepts for the generation and application of genetically engineered CAR-T and TCR-T cells
por: Hiltensperger, Michael, et al.
Publicado: (2023)

Therapeutic targeting of PRAME with (mTCR)CAR T cells in acute myeloid leukemia
por: Kirkey, Danielle C., et al.
Publicado: (2022)

Preclinical Assessment of CAR T-Cell Therapy Targeting the Tumor Antigen 5T4 in Ovarian Cancer
por: Owens, Gemma L., et al.
Publicado: (2018)

The Src-Family Kinases SRC and BLK Contribute to the CLDN6-Adhesion Signaling
por: Ichikawa-Tomikawa, Naoki, et al.
Publicado: (2023)

Integration of a CD19 CAR into the TCR Alpha Chain Locus Streamlines Production of Allogeneic Gene-Edited CAR T Cells
por: MacLeod, Daniel T., et al.
Publicado: (2017)

TCR repertoire sequencing identifies synovial Treg cell clonotypes in the bloodstream during active inflammation in human arthritis
por: Rossetti, Maura, et al.
Publicado: (2017)

Regulation of the Src Family Kinases by Csk
por: Okada, Masato
Publicado: (2012)

Nuclear Functions of the Tyrosine Kinase Src
por: Bagnato, Giulia, et al.
Publicado: (2020)

Single-Domain Antibody-Based TCR-Like CAR-T: A Potential Cancer Therapy
por: Zhu, Lichen, et al.
Publicado: (2020)

Comparing CAR and TCR engineered T cell performance as a function of tumor cell exposure
por: Wachsmann, Tassilo L. A., et al.
Publicado: (2022)

CRASH-IT Switch Enables Reversible and Dose-Dependent Control of TCR and CAR T-cell Function
por: Sahillioglu, Ali Can, et al.
Publicado: (2021)

Establishment and validation of in-house cryopreserved CAR/TCR-T cell flow cytometry quality control
por: Cai, Yihua, et al.
Publicado: (2021)

Exploring TCR-like CAR-Engineered Lymphocyte Cytotoxicity against MAGE-A4
por: Alsalloum, Alaa, et al.
Publicado: (2023)

Development of Engineered CAR T Cells Targeting Tumor-Associated Glycoforms of MUC1 for the Treatment of Intrahepatic Cholangiocarcinoma
por: Mao, Li, et al.
Publicado: (2023)

PBX1 attributes as a determinant of connexin 32 downregulation in Helicobacter pylori-related gastric carcinogenesis
por: Liu, Xiao-Ming, et al.
Publicado: (2017)

Protein tyrosine kinase 6 regulates activation of SRC kinase
por: Alwanian, Wanian M., et al.
Publicado: (2022)

Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn
por: Bloch-Queyrat, Coralie, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_tfpkqmmtl2ds468ife38fnueru