Recombinant Activated Protein C (rhAPC) Affects Lipopolysaccharide-Induced Mechanical Compliance Changes and Beat Frequency of mESC-Derived Cardiomyocyte Monolayers

BACKGROUND: Septic cardiomyopathy increases mortality by 70% to 90% and results in mechanical dysfunction of cells. METHODS: Here, we created a LPS-induced in-vitro sepsis model with mouse embryonic stem cell-derived cardiomyocytes (mESC-CM) using the CellDrum technology which simultaneously measure...

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Detalles Bibliográficos
Autores principales: Temiz Artmann, Aysegül, Kurulgan Demirci, Eylem, Fırat, Ipek Seda, Oflaz, Hakan, Artmann, Gerhard M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Basic Science Aspects
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906254/
https://www.ncbi.nlm.nih.gov/pubmed/34416756
http://dx.doi.org/10.1097/SHK.0000000000001845

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