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A Clinicopathological Study to Assess the Role of Intralesional Sclerotherapy Following Propranolol Treatment in Infantile Hemangioma

CONTEXT: As propranolol has emerged as first-line therapy for problematic infantile hemangioma, the number of non-responders and partial responders to propranolol therapy is also increasing. AIMS: The study was conducted to evaluate the response of intralesional bleomycin, triamcinolone, and a combi...

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Autores principales: Kumar, Rakesh, Tiwari, Preeti, Pandey, Vaibhav, Kar, Amrita Ghosh, Tiwary, Narendra, Sharma, Shiv Prasad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906266/
https://www.ncbi.nlm.nih.gov/pubmed/35283595
http://dx.doi.org/10.4103/JCAS.JCAS_103_20
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author Kumar, Rakesh
Tiwari, Preeti
Pandey, Vaibhav
Kar, Amrita Ghosh
Tiwary, Narendra
Sharma, Shiv Prasad
author_facet Kumar, Rakesh
Tiwari, Preeti
Pandey, Vaibhav
Kar, Amrita Ghosh
Tiwary, Narendra
Sharma, Shiv Prasad
author_sort Kumar, Rakesh
collection PubMed
description CONTEXT: As propranolol has emerged as first-line therapy for problematic infantile hemangioma, the number of non-responders and partial responders to propranolol therapy is also increasing. AIMS: The study was conducted to evaluate the response of intralesional bleomycin, triamcinolone, and a combination of both as second line of treatment for the residual hemangioma following propranolol therapy SETTINGS AND DESIGN: A prospective comparative study was conducted in patients who were either non-responders or partial responders to previous propranolol treatment. MATERIALS AND METHODS: The patients randomly received injection bleomycin, injection triamcinolone, and combination of both bleomycin and triamcinolone. The response to treatment was recorded clinically by using photographs. The pathological response was assessed by calculating pre-treatment and post-treatment microvessel density in biopsy of lesion from the non-cosmetic sites using immunohistochemistry. STATISTICAL ANALYSIS USED: χ(2) test was used to test the association between the variables. The utility of microvessel diameter (MVD) in terms of clinical response to the therapy was predicted by using receiver operating characteristic (ROC) curve. RESULTS: Out of the 134 patients, 42 received bleomycin and 44 received triamcinolone and were treated with a combination of both. The overall clinical response was better in the combination group compared with the bleomycin group (P = 0.018) and triamcinolone group (P = 0.0005), respectively, after 6 months of follow-up. There was no difference in clinical response between the triamcinolone and bleomycin groups. Change in MVD correlated with the clinical response. CONCLUSION: The combination of bleomycin and triamcinolone is effective and safe for the treatment of residual hemangioma.
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spelling pubmed-89062662022-03-10 A Clinicopathological Study to Assess the Role of Intralesional Sclerotherapy Following Propranolol Treatment in Infantile Hemangioma Kumar, Rakesh Tiwari, Preeti Pandey, Vaibhav Kar, Amrita Ghosh Tiwary, Narendra Sharma, Shiv Prasad J Cutan Aesthet Surg Original Article CONTEXT: As propranolol has emerged as first-line therapy for problematic infantile hemangioma, the number of non-responders and partial responders to propranolol therapy is also increasing. AIMS: The study was conducted to evaluate the response of intralesional bleomycin, triamcinolone, and a combination of both as second line of treatment for the residual hemangioma following propranolol therapy SETTINGS AND DESIGN: A prospective comparative study was conducted in patients who were either non-responders or partial responders to previous propranolol treatment. MATERIALS AND METHODS: The patients randomly received injection bleomycin, injection triamcinolone, and combination of both bleomycin and triamcinolone. The response to treatment was recorded clinically by using photographs. The pathological response was assessed by calculating pre-treatment and post-treatment microvessel density in biopsy of lesion from the non-cosmetic sites using immunohistochemistry. STATISTICAL ANALYSIS USED: χ(2) test was used to test the association between the variables. The utility of microvessel diameter (MVD) in terms of clinical response to the therapy was predicted by using receiver operating characteristic (ROC) curve. RESULTS: Out of the 134 patients, 42 received bleomycin and 44 received triamcinolone and were treated with a combination of both. The overall clinical response was better in the combination group compared with the bleomycin group (P = 0.018) and triamcinolone group (P = 0.0005), respectively, after 6 months of follow-up. There was no difference in clinical response between the triamcinolone and bleomycin groups. Change in MVD correlated with the clinical response. CONCLUSION: The combination of bleomycin and triamcinolone is effective and safe for the treatment of residual hemangioma. Wolters Kluwer - Medknow 2021 /pmc/articles/PMC8906266/ /pubmed/35283595 http://dx.doi.org/10.4103/JCAS.JCAS_103_20 Text en Copyright: © 2022 Journal of Cutaneous and Aesthetic Surgery https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Kumar, Rakesh
Tiwari, Preeti
Pandey, Vaibhav
Kar, Amrita Ghosh
Tiwary, Narendra
Sharma, Shiv Prasad
A Clinicopathological Study to Assess the Role of Intralesional Sclerotherapy Following Propranolol Treatment in Infantile Hemangioma
title A Clinicopathological Study to Assess the Role of Intralesional Sclerotherapy Following Propranolol Treatment in Infantile Hemangioma
title_full A Clinicopathological Study to Assess the Role of Intralesional Sclerotherapy Following Propranolol Treatment in Infantile Hemangioma
title_fullStr A Clinicopathological Study to Assess the Role of Intralesional Sclerotherapy Following Propranolol Treatment in Infantile Hemangioma
title_full_unstemmed A Clinicopathological Study to Assess the Role of Intralesional Sclerotherapy Following Propranolol Treatment in Infantile Hemangioma
title_short A Clinicopathological Study to Assess the Role of Intralesional Sclerotherapy Following Propranolol Treatment in Infantile Hemangioma
title_sort clinicopathological study to assess the role of intralesional sclerotherapy following propranolol treatment in infantile hemangioma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906266/
https://www.ncbi.nlm.nih.gov/pubmed/35283595
http://dx.doi.org/10.4103/JCAS.JCAS_103_20
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