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Characterizing Heparin Tetrasaccharides Binding to Amyloid-Beta Peptide

The aggregation of β-amyloid peptide (Aβ) is one potential cause for Alzheimer’s disease (AD). Heparin can either promote or inhibit Aβ aggregation. The sulfation pattern and chain size determine its binding affinity and its role. Using 2D-NMR analysis and molecular modelling, the binding motif of h...

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Detalles Bibliográficos
Autores principales:	Zhou, Xiang, Wang, Yuanyuan, Zheng, Wei, Deng, Guangxiu, Wang, Fuyi, Jin, Lan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906399/ https://www.ncbi.nlm.nih.gov/pubmed/35281253 http://dx.doi.org/10.3389/fmolb.2022.824146

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