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5′ preS1 Mutations To Prevent Large Envelope Protein Expression from Hepatitis B Virus Genotype A or Genotype D Markedly Increase Polymerase-Envelope Fusion Protein

Hepatitis B virus (HBV) large (L) envelope protein is translated from 2.4-kb RNA. It contains preS1, preS2, and S domains and is detected in Western blotting as p39 and gp42. The 3.5-kb pregenomic RNA produces core and polymerase (P) proteins. We generated L-minus mutants of a genotype A clone and a...

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Detalles Bibliográficos
Autores principales:	Zhang, Jing, Yuan, Quan, Wang, Yongxiang, Wang, Yuzhou, Yuan, Wenqing, Xia, Ningshao, Wen, Yumei, Li, Jisu, Tong, Shuping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Genome Replication and Regulation of Viral Gene Expression
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906437/ https://www.ncbi.nlm.nih.gov/pubmed/35019714 http://dx.doi.org/10.1128/jvi.01723-21

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