Mechanosensitive calcium flashes promote sustained RhoA activation during tight junction remodeling

Epithelial cell–cell junctions remodel in response to mechanical stimuli to maintain barrier function. Previously, we found that local leaks in tight junctions (TJs) are rapidly repaired by local, transient RhoA activation, termed “Rho flares,” but how Rho flares are regulated is unknown. Here, we d...

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Detalles Bibliográficos
Autores principales: Varadarajan, Saranyaraajan, Chumki, Shahana A., Stephenson, Rachel E., Misterovich, Eileen R., Wu, Jessica L., Dudley, Claire E., Erofeev, Ivan S., Goryachev, Andrew B., Miller, Ann L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906493/
https://www.ncbi.nlm.nih.gov/pubmed/35254388
http://dx.doi.org/10.1083/jcb.202105107

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