Correlation of nuclear pIGF-1R/IGF-1R and YAP/TAZ in a tissue microarray with outcomes in osteosarcoma patients

Osteosarcoma (OS) is a genetically diverse bone cancer that lacks a consistent targetable mutation. Recent studies suggest the IGF/PI3K/mTOR pathway and YAP/TAZ paralogs regulate cell fate and proliferation in response to biomechanical cues within the tumor microenvironment. How this occurs and thei...

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Detalles Bibliográficos
Autores principales: Molina, Eric R., Chim, Letitia K., Lamhamedi-Cherradi, Salah-Eddine, Mohiuddin, Sana, McCall, David, Cuglievan, Branko, Krishnan, Sandhya, Porter, Robert W., Ingram, Davis R., Wang, Wei-Lien, Lazar, Alexander J., Scott, David W., Truong, Danh D., Daw, Najat C., Ludwig, Joseph A., Mikos, Antonios G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906536/
https://www.ncbi.nlm.nih.gov/pubmed/35284040
http://dx.doi.org/10.18632/oncotarget.28215

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