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The role of childrens’ vaccination for COVID-19—Pareto-optimal allocations of vaccines

COVID-19 vaccines have been approved for children of age five and older in many countries. However, there is an ongoing debate as to whether children should be vaccinated and at what priority. In this work, we use mathematical modeling and optimization to study how vaccine allocations to different a...

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Detalles Bibliográficos
Autores principales: Gavish, Nir, Katriel, Guy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906616/
https://www.ncbi.nlm.nih.gov/pubmed/35213541
http://dx.doi.org/10.1371/journal.pcbi.1009872
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author Gavish, Nir
Katriel, Guy
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Katriel, Guy
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description COVID-19 vaccines have been approved for children of age five and older in many countries. However, there is an ongoing debate as to whether children should be vaccinated and at what priority. In this work, we use mathematical modeling and optimization to study how vaccine allocations to different age groups effect epidemic outcomes. In particular, we consider the effect of extending vaccination campaigns to include the vaccination of children. When vaccine availability is limited, we consider Pareto-optimal allocations with respect to competing measures of the number of infections and mortality and systematically study the trade-offs among them. In the scenarios considered, when some weight is given to the number of infections, we find that it is optimal to allocate vaccines to adolescents in the age group 10-19, even when they are assumed to be less susceptible than adults. We further find that age group 0-9 is included in the optimal allocation for sufficiently high values of the basic reproduction number.
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spelling pubmed-89066162022-03-10 The role of childrens’ vaccination for COVID-19—Pareto-optimal allocations of vaccines Gavish, Nir Katriel, Guy PLoS Comput Biol Research Article COVID-19 vaccines have been approved for children of age five and older in many countries. However, there is an ongoing debate as to whether children should be vaccinated and at what priority. In this work, we use mathematical modeling and optimization to study how vaccine allocations to different age groups effect epidemic outcomes. In particular, we consider the effect of extending vaccination campaigns to include the vaccination of children. When vaccine availability is limited, we consider Pareto-optimal allocations with respect to competing measures of the number of infections and mortality and systematically study the trade-offs among them. In the scenarios considered, when some weight is given to the number of infections, we find that it is optimal to allocate vaccines to adolescents in the age group 10-19, even when they are assumed to be less susceptible than adults. We further find that age group 0-9 is included in the optimal allocation for sufficiently high values of the basic reproduction number. Public Library of Science 2022-02-25 /pmc/articles/PMC8906616/ /pubmed/35213541 http://dx.doi.org/10.1371/journal.pcbi.1009872 Text en © 2022 Gavish, Katriel https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Gavish, Nir
Katriel, Guy
The role of childrens’ vaccination for COVID-19—Pareto-optimal allocations of vaccines
title The role of childrens’ vaccination for COVID-19—Pareto-optimal allocations of vaccines
title_full The role of childrens’ vaccination for COVID-19—Pareto-optimal allocations of vaccines
title_fullStr The role of childrens’ vaccination for COVID-19—Pareto-optimal allocations of vaccines
title_full_unstemmed The role of childrens’ vaccination for COVID-19—Pareto-optimal allocations of vaccines
title_short The role of childrens’ vaccination for COVID-19—Pareto-optimal allocations of vaccines
title_sort role of childrens’ vaccination for covid-19—pareto-optimal allocations of vaccines
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906616/
https://www.ncbi.nlm.nih.gov/pubmed/35213541
http://dx.doi.org/10.1371/journal.pcbi.1009872
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