Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA

We report a case of resistance development toward cefiderocol in a patient with intra-abdominal and bloodstream infections caused by carbapenemase-producing Enterobacter cloacae within 21 days of cefiderocol therapy. Whole genome sequencing revealed heterogeneous mutations in the cirA gene, encoding...

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Detalles Bibliográficos
Autores principales: Klein, Sabrina, Boutin, Sébastien, Kocer, Kaan, Fiedler, Mascha O, Störzinger, Dominic, Weigand, Markus A, Tan, Benjamin, Richter, Daniel, Rupp, Christian, Mieth, Markus, Mehrabi, Arianeb, Hackert, Thilo, Zimmermann, Stefan, Heeg, Klaus, Nurjadi, Dennis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906715/
https://www.ncbi.nlm.nih.gov/pubmed/34079986
http://dx.doi.org/10.1093/cid/ciab511
Descripción
Sumario:We report a case of resistance development toward cefiderocol in a patient with intra-abdominal and bloodstream infections caused by carbapenemase-producing Enterobacter cloacae within 21 days of cefiderocol therapy. Whole genome sequencing revealed heterogeneous mutations in the cirA gene, encoding a catecholate siderophore receptor, conferring phenotypic resistance to cefiderocol.

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