Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA

We report a case of resistance development toward cefiderocol in a patient with intra-abdominal and bloodstream infections caused by carbapenemase-producing Enterobacter cloacae within 21 days of cefiderocol therapy. Whole genome sequencing revealed heterogeneous mutations in the cirA gene, encoding...

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Autores principales: Klein, Sabrina, Boutin, Sébastien, Kocer, Kaan, Fiedler, Mascha O, Störzinger, Dominic, Weigand, Markus A, Tan, Benjamin, Richter, Daniel, Rupp, Christian, Mieth, Markus, Mehrabi, Arianeb, Hackert, Thilo, Zimmermann, Stefan, Heeg, Klaus, Nurjadi, Dennis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906715/
https://www.ncbi.nlm.nih.gov/pubmed/34079986
http://dx.doi.org/10.1093/cid/ciab511
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author Klein, Sabrina
Boutin, Sébastien
Kocer, Kaan
Fiedler, Mascha O
Störzinger, Dominic
Weigand, Markus A
Tan, Benjamin
Richter, Daniel
Rupp, Christian
Mieth, Markus
Mehrabi, Arianeb
Hackert, Thilo
Zimmermann, Stefan
Heeg, Klaus
Nurjadi, Dennis
author_facet Klein, Sabrina
Boutin, Sébastien
Kocer, Kaan
Fiedler, Mascha O
Störzinger, Dominic
Weigand, Markus A
Tan, Benjamin
Richter, Daniel
Rupp, Christian
Mieth, Markus
Mehrabi, Arianeb
Hackert, Thilo
Zimmermann, Stefan
Heeg, Klaus
Nurjadi, Dennis
author_sort Klein, Sabrina
collection PubMed
description We report a case of resistance development toward cefiderocol in a patient with intra-abdominal and bloodstream infections caused by carbapenemase-producing Enterobacter cloacae within 21 days of cefiderocol therapy. Whole genome sequencing revealed heterogeneous mutations in the cirA gene, encoding a catecholate siderophore receptor, conferring phenotypic resistance to cefiderocol.
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spelling pubmed-89067152022-03-10 Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA Klein, Sabrina Boutin, Sébastien Kocer, Kaan Fiedler, Mascha O Störzinger, Dominic Weigand, Markus A Tan, Benjamin Richter, Daniel Rupp, Christian Mieth, Markus Mehrabi, Arianeb Hackert, Thilo Zimmermann, Stefan Heeg, Klaus Nurjadi, Dennis Clin Infect Dis Brief Reports We report a case of resistance development toward cefiderocol in a patient with intra-abdominal and bloodstream infections caused by carbapenemase-producing Enterobacter cloacae within 21 days of cefiderocol therapy. Whole genome sequencing revealed heterogeneous mutations in the cirA gene, encoding a catecholate siderophore receptor, conferring phenotypic resistance to cefiderocol. Oxford University Press 2021-06-03 /pmc/articles/PMC8906715/ /pubmed/34079986 http://dx.doi.org/10.1093/cid/ciab511 Text en © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Reports
Klein, Sabrina
Boutin, Sébastien
Kocer, Kaan
Fiedler, Mascha O
Störzinger, Dominic
Weigand, Markus A
Tan, Benjamin
Richter, Daniel
Rupp, Christian
Mieth, Markus
Mehrabi, Arianeb
Hackert, Thilo
Zimmermann, Stefan
Heeg, Klaus
Nurjadi, Dennis
Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA
title Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA
title_full Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA
title_fullStr Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA
title_full_unstemmed Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA
title_short Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA
title_sort rapid development of cefiderocol resistance in carbapenem-resistant enterobacter cloacae during therapy is associated with heterogeneous mutations in the catecholate siderophore receptor cira
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906715/
https://www.ncbi.nlm.nih.gov/pubmed/34079986
http://dx.doi.org/10.1093/cid/ciab511
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