The Antidiabetic Drug Metformin Regulates Voltage-Gated Sodium Channel Na(V)1.7 via the Ubiquitin-Ligase NEDD4-2

The antidiabetic drug metformin has been shown to reduce pain hypersensitivity in preclinical models of chronic pain and in neuropathic pain in humans. Multiple intracellular pathways have been described as metformin targets. Among them, metformin is an activator of the adenosine 5′-monophosphate pr...

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Detalles Bibliográficos
Autores principales: Deftu, Alexandru-Florian, Chu Sin Chung, Paul, Laedermann, Cédric J., Gillet, Ludovic, Pertin, Marie, Kirschmann, Guylène, Decosterd, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2022
Materias:
Research Article: New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906783/
https://www.ncbi.nlm.nih.gov/pubmed/35131865
http://dx.doi.org/10.1523/ENEURO.0409-21.2022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906783/
https://www.ncbi.nlm.nih.gov/pubmed/35131865
http://dx.doi.org/10.1523/ENEURO.0409-21.2022

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