Safety and immunogenicity of a synthetic multiantigen modified vaccinia virus Ankara-based COVID-19 vaccine (COH04S1): an open-label and randomised, phase 1 trial

BACKGROUND: COH04S1, a synthetic attenuated modified vaccinia virus Ankara vector co-expressing SARS-CoV-2 spike and nucleocapsid antigens, was tested for safety and immunogenicity in healthy adults. METHODS: This combined open-label and randomised, phase 1 trial was done at the City of Hope Compreh...

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Autores principales: Chiuppesi, Flavia, Zaia, John A, Frankel, Paul H, Stan, Rodica, Drake, Jennifer, Williams, Brenda, Acosta, Anne Marie, Francis, Karyn, Taplitz, Randy A, Dickter, Janet K, Dadwal, Sanjeet, Puing, Alfredo G, Nanayakkara, Deepa D, Ash, Patricia, Cui, Yujie, Contreras, Heidi, La Rosa, Corinna, Tiemann, Katrin, Park, Yoonsuh, Medina, Joybelle, Iniguez, Angelina, Zhou, Qiao, Karpinski, Veronica, Johnson, Daisy, Faircloth, Katelyn, Kaltcheva, Teadora, Nguyen, Jenny, Kha, Mindy, Nguyen, Vu H, Francisco, Sandra Ortega, Grifoni, Alba, Wong, Angela, Sette, Alessandro, Wussow, Felix, Diamond, Don J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906816/
https://www.ncbi.nlm.nih.gov/pubmed/35287430
http://dx.doi.org/10.1016/S2666-5247(22)00027-1

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