Cargando…

Solasonine Induces Apoptosis and Inhibits Proliferation of Bladder Cancer Cells by Suppressing NRP1 Expression

Solasonine, a steroidal alkaloid extracted from Solanum nigrum L., has been found to exert inhibitory effect on cancers. However, the underlying anticancer mechanisms of solasonine, particularly in urinary bladder cancer (BC), remain unclear. In this study, we identified the potential targets and bi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dong, Yang, Hao, Lin, Shi, Zhen-duo, Fang, Kun, Yu, Hui, Zang, Guang-hui, Fan, Tao, Han, Cong-hui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906937/ https://www.ncbi.nlm.nih.gov/pubmed/35281516 http://dx.doi.org/10.1155/2022/7261486

Ejemplares similares

Role of NRP1 in Bladder Cancer Pathogenesis and Progression
por: Dong, Yang, et al.
Publicado: (2021)

Solasonine Suppresses the Proliferation of Acute Monocytic Leukemia Through the Activation of the AMPK/FOXO3A Axis
por: Zhang, Hong, et al.
Publicado: (2021)

Tumor necrosis factor-related apoptosis-inducing ligand inhibits proliferation and induces apoptosis of prostate and bladder cancer cells
por: Hao, Lin, et al.
Publicado: (2017)

Solasonine Inhibits Pancreatic Cancer Progression With Involvement of Ferroptosis Induction
por: Liang, Xiaoqiang, et al.
Publicado: (2022)

Solasonine, A Natural Glycoalkaloid Compound, Inhibits Gli-Mediated Transcriptional Activity
por: Yang, Jun, et al.
Publicado: (2016)

Solasonine Causes Redox Imbalance and Mitochondrial Oxidative Stress of Ferroptosis in Lung Adenocarcinoma
por: Zeng, Yao-Ying, et al.
Publicado: (2022)

Solasonine induces apoptosis of the SGC‐7901 human gastric cancer cell line in vitro via the mitochondria‐mediated pathway
por: Li, Tian‐Chuan, et al.
Publicado: (2022)

Linking NRP2 With EMT and Chemoradioresistance in Bladder Cancer
por: Schulz, Alexander, et al.
Publicado: (2020)

miR-331-3p Suppresses Cell Proliferation in TNBC Cells by Downregulating NRP2
por: Zhao, Mingchuan, et al.
Publicado: (2020)

Expression of NRP-1 and NRP-2 in Endometrial Cancer
por: Oplawski, Marcin, et al.
Publicado: (2019)

NRP1 regulates autophagy and proliferation of gastric cancer through Wnt/β-catenin signaling pathway
por: Yu, Qi-Ying, et al.
Publicado: (2023)

Solanum nigrum Extract and Solasonine Affected Hemolymph Metabolites and Ultrastructure of the Fat Body and the Midgut in Galleria mellonella
por: Spochacz, Marta, et al.
Publicado: (2021)

siRNA Suppression of NEDD9 Inhibits Proliferation and Enhances Apoptosis in Renal Cell Carcinoma
por: Wang, Jue, et al.
Publicado: (2015)

Segregation Analysis of Rare NRP1 and NRP2 Variants in Families with Lymphedema
por: Michelini, Sandro, et al.
Publicado: (2020)

Propranolol suppresses the proliferation and induces the apoptosis of liver cancer cells
por: Wang, Fang, et al.
Publicado: (2018)

Suppressed OGT expression inhibits cell proliferation while inducing cell apoptosis in bladder cancer
por: Wang, Longsheng, et al.
Publicado: (2018)

UBE2T silencing suppresses proliferation and induces cell cycle arrest and apoptosis in bladder cancer cells
por: Gong, Yan Qing, et al.
Publicado: (2016)

Pancancer Analysis of Neurovascular-Related NRP Family Genes as Potential Prognostic Biomarkers of Bladder Urothelial Carcinoma
por: Deng, Chao, et al.
Publicado: (2021)

Plasmodium infection suppresses colon cancer growth by inhibiting proliferation and promoting apoptosis associated with disrupting mitochondrial biogenesis and mitophagy in mice
por: Yao, Xin, et al.
Publicado: (2022)

Analysis of PLXNA1, NRP1, and NRP2 variants in a cohort of patients with isolated hypogonadotropic hypogonadism
por: Men, Meichao, et al.
Publicado: (2021)

Anti-Colorectal Cancer Activity of Solasonin from Solanum nigrum L. via Histone Deacetylases-Mediated p53 Acetylation Pathway
por: Lan, Xintian, et al.
Publicado: (2023)

Knockdown of P3H4 inhibits proliferation and invasion of bladder cancer
por: Hao, Lin, et al.
Publicado: (2020)

NRP1 and synapse formation
por: Ango, Fabrice
Publicado: (2016)

Effects of disodium cantharidinate on dendritic cells of patients with bladder carcinoma
por: Zang, Guang-Hui, et al.
Publicado: (2018)

CaMKK2 Suppresses Muscle Regeneration through the Inhibition of Myoblast Proliferation and Differentiation
por: Ye, Cheng, et al.
Publicado: (2016)

Devazepide suppresses cell proliferation and migration, and induces apoptosis in bladder carcinoma
por: Zhang, Hengzhe, et al.
Publicado: (2021)

Wedelolactone Enhances Osteoblastogenesis but Inhibits Osteoclastogenesis through Sema3A/NRP1/PlexinA1 Pathway
por: Liu, Yan-Qiu, et al.
Publicado: (2016)

NRP-1 silencing suppresses hepatocellular carcinoma cell growth in vitro and in vivo
por: XU, JING, et al.
Publicado: (2013)

Evaluation of diagnostic efficacy of NRP‐1/CD304 in hematological diseases
por: Liu, Yi‐jun, et al.
Publicado: (2023)

In Vivo Toxicity of Solasonine and Its Effects on cyp450 Family Gene Expression in the Livers of Male Mice from Four Strains
por: Zhong, Youbao, et al.
Publicado: (2018)

MicroRNA-198 inhibits proliferation and induces apoptosis by directly suppressing FGFR1 in gastric cancer
por: Gu, Junxia, et al.
Publicado: (2019)

Aberrant NRP-1 expression serves as predicator of metastatic endometrial and lung cancers
por: Okon, Imoh S., et al.
Publicado: (2015)

α-E-Catenin (CTNNA1) Inhibits Cell Proliferation, Invasion and EMT of Bladder Cancer
por: Chi, Qiang, et al.
Publicado: (2020)

Identification of ACHE as the hub gene targeting solasonine associated with non-small cell lung cancer (NSCLC) using integrated bioinformatics analysis
por: Liu, Tong, et al.
Publicado: (2023)

NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system
por: Maden, Charlotte H., et al.
Publicado: (2012)

VEGF(189) binds NRP1 and is sufficient for VEGF/NRP1-dependent neuronal patterning in the developing brain
por: Tillo, Miguel, et al.
Publicado: (2015)

Vascular NRP2 triggers PNET angiogenesis by activating the SSH1-cofilin axis
por: Luo, Xi, et al.
Publicado: (2020)

MicroRNA-212-3p inhibits the Proliferation and Invasion of Human Hepatocellular Carcinoma Cells by Suppressing CTGF expression
por: Chen, Jian-qing, et al.
Publicado: (2019)

MicroRNA-331-3p Suppresses Cervical Cancer Cell Proliferation and E6/E7 Expression by Targeting NRP2
por: Fujii, Tomomi, et al.
Publicado: (2016)

Tetrandrine suppresses proliferation, induces apoptosis, and inhibits migration and invasion in human prostate cancer cells
por: Liu, Wei, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_l81fkjo9ik7lv103p6slpvthhc