Cargando…

STING Induces Liver Ischemia-Reperfusion Injury by Promoting Calcium-Dependent Caspase 1-GSDMD Processing in Macrophages

OBJECTIVES: Although a recent study reported that stimulator of interferon genes (STING) in macrophages has an important regulatory effect on liver ischemia-reperfusion injury (IRI), the underlying mechanism of STING-dependent innate immune activation in liver macrophages (Kupffer cells, KCs) remain...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Xin-yi, Chen, Ya-jun, Liu, Chang-an, Gong, Jun-hua, Xu, Xue-song
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906939/ https://www.ncbi.nlm.nih.gov/pubmed/35281468 http://dx.doi.org/10.1155/2022/8123157

Ejemplares similares

Disulfiram ameliorates ischemia/reperfusion-induced acute kidney injury by suppressing the caspase-11-GSDMD pathway
por: Cai, Qiaoting, et al.
Publicado: (2022)

Puerarin protects renal ischemia-reperfusion injury in rats through NLRP3/Caspase-1/GSDMD pathway
por: Wang, Kangyu, et al.
Publicado: (2023)

GSDMD promotes neutrophil extracellular traps via mtDNA-cGAS-STING pathway during lung ischemia/reperfusion
por: Zhao, Chen, et al.
Publicado: (2023)

Ellagic acid Alleviates hepatic ischemia–reperfusion injury in C57 mice via the Caspase-1-GSDMD pathway
por: Wang, Hao, et al.
Publicado: (2022)

Blocking GSDMD processing in innate immune cells but not in hepatocytes protects hepatic ischemia–reperfusion injury
por: Li, Jichang, et al.
Publicado: (2020)

Hydrogen Sulfide Attenuates Neuroinflammation by Inhibiting the NLRP3/Caspase-1/GSDMD Pathway in Retina or Brain Neuron following Rat Ischemia/Reperfusion
por: Yang, Kun-Li, et al.
Publicado: (2022)

Downregulated XBP-1 Rescues Cerebral Ischemia/Reperfusion Injury-Induced Pyroptosis via the NLRP3/Caspase-1/GSDMD Axis
por: Zhang, Yueting, et al.
Publicado: (2022)

Aging aggravated liver ischemia and reperfusion injury by promoting STING‐mediated NLRP3 activation in macrophages
por: Zhong, Weizhe, et al.
Publicado: (2020)

Oridonin Protects against Myocardial Ischemia–Reperfusion Injury by Inhibiting GSDMD-Mediated Pyroptosis
por: Lin, Jiahui, et al.
Publicado: (2022)

Association of GSDMD with microvascular-ischemia reperfusion injury after ST-elevation myocardial infarction
por: Sun, Wenjing, et al.
Publicado: (2023)

Tetracaine hydrochloride induces macrophage pyroptosis through caspase‑1/11‑GSDMD signaling pathways
por: Zhang, Ran, et al.
Publicado: (2023)

Inhibition of GSDMD Activates Poly(ADP-ribosyl)ation and Promotes Myocardial Ischemia-Reperfusion Injury
por: Zhang, Zheng-hao, et al.
Publicado: (2022)

mtDNA-STING pathway promotes necroptosis-dependent enterocyte injury in intestinal ischemia reperfusion
por: Zhang, Xufei, et al.
Publicado: (2020)

GSDMD contributes to myocardial reperfusion injury by regulating pyroptosis
por: Ye, Xiaomiao, et al.
Publicado: (2022)

Macrophage Polarization and Liver Ischemia-Reperfusion Injury
por: Wang, Hai, et al.
Publicado: (2021)

Blocking Caspase-1/Gsdmd and Caspase-3/-8/Gsdme pyroptotic pathways rescues silicosis in mice
por: Kang, Lulu, et al.
Publicado: (2022)

Puerarin Inhibits NLRP3-Caspase-1-GSDMD-Mediated Pyroptosis via P2X7 Receptor in Cardiomyocytes and Macrophages
por: Sun, Shuchan, et al.
Publicado: (2023)

Cold Stress Induced Liver Injury of Mice through Activated NLRP3/Caspase-1/GSDMD Pyroptosis Signaling Pathway
por: Liu, Yuanyuan, et al.
Publicado: (2022)

Ophiopogonin B alleviates cisplatin resistance of lung cancer cells by inducing Caspase-1/GSDMD dependent pyroptosis
por: Cheng, Ziyu, et al.
Publicado: (2022)

Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway
por: Jia, Yifan, et al.
Publicado: (2020)

Myoglobin promotes macrophage polarization to M1 type and pyroptosis via the RIG-I/Caspase1/GSDMD signaling pathway in CS-AKI
por: Li, Ning, et al.
Publicado: (2022)

Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway
por: Yang, Ye, et al.
Publicado: (2020)

Mesenchymal stem cell-derived exosomal microRNA-182-5p alleviates myocardial ischemia/reperfusion injury by targeting GSDMD in mice
por: Yue, Rongchuan, et al.
Publicado: (2022)

Jatrorrhizine Suppresses Murine-Norovirus-Triggered N-GSDMD-Dependent Pyroptosis in RAW264.7 Macrophages
por: Fu, Ming, et al.
Publicado: (2023)

Mycobacterium tuberculosis PE_PGRS19 Induces Pyroptosis through a Non-Classical Caspase-11/GSDMD Pathway in Macrophages
por: Qian, Jianing, et al.
Publicado: (2022)

Simvastatin induces pyroptosis via ROS/caspase-1/GSDMD pathway in colon cancer
por: Xie, Wei, et al.
Publicado: (2023)

Liver Ischemia Reperfusion Injury, Enhanced by Trained Immunity, Is Attenuated in Caspase 1/Caspase 11 Double Gene Knockout Mice
por: Fagenson, Alexander M., et al.
Publicado: (2020)

Dual Effect of Hepatic Macrophages on Liver Ischemia and Reperfusion Injury during Liver Transplantation
por: Lu, Tian-Fei, et al.
Publicado: (2018)

Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation
por: Wang, Yufang, et al.
Publicado: (2019)

Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD
por: Heilig, Rosalie, et al.
Publicado: (2020)

Secoisolariciresinol diglucoside induces pyroptosis by activating caspase‐1 to cleave GSDMD in colorectal cancer cells
por: Chen, Tuo, et al.
Publicado: (2022)

MLKL deficiency attenuated hepatocyte oxidative DNA damage by activating mitophagy to suppress macrophage cGAS-STING signaling during liver ischemia and reperfusion injury
por: Xu, Jian, et al.
Publicado: (2023)

Review: the role of GSDMD in sepsis
por: Shao, Ruifei, et al.
Publicado: (2022)

Computational research of Belnacasan and new Caspase-1 inhibitor on cerebral ischemia reperfusion injury
por: Li, Hui, et al.
Publicado: (2022)

Stromal Cell-Derived Factor-1α Alleviates Calcium-Sensing Receptor Activation-Mediated Ischemia/Reperfusion Injury by Inhibiting Caspase-3/Caspase-9-Induced Cell Apoptosis in Rat Free Flaps
por: Song, Li, et al.
Publicado: (2018)

TSPO Deficiency Exacerbates GSDMD-Mediated Macrophage Pyroptosis in Inflammatory Bowel Disease
por: Zhang, Xue, et al.
Publicado: (2022)

The effects of simvastatin preconditioning on the expression of caspase-3 after myocardial ischemia reperfusion injury in rats
por: Sun, Weixin, et al.
Publicado: (2019)

Pan-caspase inhibitor F573 mitigates liver ischemia reperfusion injury in a murine model
por: Bral, Mariusz, et al.
Publicado: (2019)

Tisp40 Induces Tubular Epithelial Cell GSDMD-Mediated Pyroptosis in Renal Ischemia-Reperfusion Injury via NF-κB Signaling
por: Xiao, Chengcheng, et al.
Publicado: (2020)

Moxibustion against Cyclophosphamide-Induced Premature Ovarian Failure in Rats through Inhibiting NLRP3-/Caspase-1-/GSDMD-Dependent Pyroptosis
por: Zhang, Cai-rong, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_l4vs0ll373acsjep60ijjiah7u