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Neurons-on-a-Chip: In Vitro NeuroTools
Neurons-on-a-Chip technology has been developed to provide diverse in vitro neuro-tools to study neuritogenesis, synaptogensis, axon guidance, and network dynamics. The two core enabling technologies are soft-lithography and microelectrode array technology. Soft lithography technology made it possib...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Molecular and Cellular Biology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906998/ https://www.ncbi.nlm.nih.gov/pubmed/35236782 http://dx.doi.org/10.14348/molcells.2022.2023 |
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author | Hong, Nari Nam, Yoonkey |
author_facet | Hong, Nari Nam, Yoonkey |
author_sort | Hong, Nari |
collection | PubMed |
description | Neurons-on-a-Chip technology has been developed to provide diverse in vitro neuro-tools to study neuritogenesis, synaptogensis, axon guidance, and network dynamics. The two core enabling technologies are soft-lithography and microelectrode array technology. Soft lithography technology made it possible to fabricate microstamps and microfluidic channel devices with a simple replica molding method in a biological laboratory and innovatively reduced the turn-around time from assay design to chip fabrication, facilitating various experimental designs. To control nerve cell behaviors at the single cell level via chemical cues, surface biofunctionalization methods and micropatterning techniques were developed. Microelectrode chip technology, which provides a functional readout by measuring the electrophysiological signals from individual neurons, has become a popular platform to investigate neural information processing in networks. Due to these key advances, it is possible to study the relationship between the network structure and functions, and they have opened a new era of neurobiology and will become standard tools in the near future. |
format | Online Article Text |
id | pubmed-8906998 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Korean Society for Molecular and Cellular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-89069982022-03-16 Neurons-on-a-Chip: In Vitro NeuroTools Hong, Nari Nam, Yoonkey Mol Cells Minireview Neurons-on-a-Chip technology has been developed to provide diverse in vitro neuro-tools to study neuritogenesis, synaptogensis, axon guidance, and network dynamics. The two core enabling technologies are soft-lithography and microelectrode array technology. Soft lithography technology made it possible to fabricate microstamps and microfluidic channel devices with a simple replica molding method in a biological laboratory and innovatively reduced the turn-around time from assay design to chip fabrication, facilitating various experimental designs. To control nerve cell behaviors at the single cell level via chemical cues, surface biofunctionalization methods and micropatterning techniques were developed. Microelectrode chip technology, which provides a functional readout by measuring the electrophysiological signals from individual neurons, has become a popular platform to investigate neural information processing in networks. Due to these key advances, it is possible to study the relationship between the network structure and functions, and they have opened a new era of neurobiology and will become standard tools in the near future. Korean Society for Molecular and Cellular Biology 2022-02-28 2022-02-15 /pmc/articles/PMC8906998/ /pubmed/35236782 http://dx.doi.org/10.14348/molcells.2022.2023 Text en © The Korean Society for Molecular and Cellular Biology. All rights reserved. https://creativecommons.org/licenses/by-nc-sa/3.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ (https://creativecommons.org/licenses/by-nc-sa/3.0/) |
spellingShingle | Minireview Hong, Nari Nam, Yoonkey Neurons-on-a-Chip: In Vitro NeuroTools |
title | Neurons-on-a-Chip: In Vitro NeuroTools |
title_full | Neurons-on-a-Chip: In Vitro NeuroTools |
title_fullStr | Neurons-on-a-Chip: In Vitro NeuroTools |
title_full_unstemmed | Neurons-on-a-Chip: In Vitro NeuroTools |
title_short | Neurons-on-a-Chip: In Vitro NeuroTools |
title_sort | neurons-on-a-chip: in vitro neurotools |
topic | Minireview |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8906998/ https://www.ncbi.nlm.nih.gov/pubmed/35236782 http://dx.doi.org/10.14348/molcells.2022.2023 |
work_keys_str_mv | AT hongnari neuronsonachipinvitroneurotools AT namyoonkey neuronsonachipinvitroneurotools |