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Inflammasome Meets Centrosome: Understanding the Emerging Role of Centrosome in Controlling Inflammasome Activation

Inflammasomes are multi-protein platforms that are assembled in response to microbial and danger signals to activate proinflammatory caspase-1 for production of active form of IL-1β and induction of pyroptotic cell death. Where and how an inflammasome is assembled in cells has remained controversial...

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Autores principales: Wu, Dandan, Zhang, Zhenzhen, Jiang, Xiaoli, Du, Yaning, Zhang, Shuangyan, Yang, Xiao-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907152/
https://www.ncbi.nlm.nih.gov/pubmed/35281071
http://dx.doi.org/10.3389/fimmu.2022.826106
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author Wu, Dandan
Zhang, Zhenzhen
Jiang, Xiaoli
Du, Yaning
Zhang, Shuangyan
Yang, Xiao-Dong
author_facet Wu, Dandan
Zhang, Zhenzhen
Jiang, Xiaoli
Du, Yaning
Zhang, Shuangyan
Yang, Xiao-Dong
author_sort Wu, Dandan
collection PubMed
description Inflammasomes are multi-protein platforms that are assembled in response to microbial and danger signals to activate proinflammatory caspase-1 for production of active form of IL-1β and induction of pyroptotic cell death. Where and how an inflammasome is assembled in cells has remained controversial. While the endoplasmic reticulum, mitochondria and Golgi apparatus have been reported to be associated with inflammasome assembly, none of these sites seems to match the morphology, number and size of activated inflammasomes that are microscopically observable as one single perinuclear micrometer-sized punctum in each cell. Recently, emerging evidence shows that NLRP3 and pyrin inflammasomes are assembled, activated and locally regulated at the centrosome, the major microtubule organizing center in mammalian cells, elegantly accounting for the singularity, size and perinuclear location of activated inflammasomes. These new exciting findings reveal the previously unappreciated importance of the centrosome in controlling inflammasome assembly and activation as well as inflammasome-related diseases.
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spelling pubmed-89071522022-03-11 Inflammasome Meets Centrosome: Understanding the Emerging Role of Centrosome in Controlling Inflammasome Activation Wu, Dandan Zhang, Zhenzhen Jiang, Xiaoli Du, Yaning Zhang, Shuangyan Yang, Xiao-Dong Front Immunol Immunology Inflammasomes are multi-protein platforms that are assembled in response to microbial and danger signals to activate proinflammatory caspase-1 for production of active form of IL-1β and induction of pyroptotic cell death. Where and how an inflammasome is assembled in cells has remained controversial. While the endoplasmic reticulum, mitochondria and Golgi apparatus have been reported to be associated with inflammasome assembly, none of these sites seems to match the morphology, number and size of activated inflammasomes that are microscopically observable as one single perinuclear micrometer-sized punctum in each cell. Recently, emerging evidence shows that NLRP3 and pyrin inflammasomes are assembled, activated and locally regulated at the centrosome, the major microtubule organizing center in mammalian cells, elegantly accounting for the singularity, size and perinuclear location of activated inflammasomes. These new exciting findings reveal the previously unappreciated importance of the centrosome in controlling inflammasome assembly and activation as well as inflammasome-related diseases. Frontiers Media S.A. 2022-02-24 /pmc/articles/PMC8907152/ /pubmed/35281071 http://dx.doi.org/10.3389/fimmu.2022.826106 Text en Copyright © 2022 Wu, Zhang, Jiang, Du, Zhang and Yang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wu, Dandan
Zhang, Zhenzhen
Jiang, Xiaoli
Du, Yaning
Zhang, Shuangyan
Yang, Xiao-Dong
Inflammasome Meets Centrosome: Understanding the Emerging Role of Centrosome in Controlling Inflammasome Activation
title Inflammasome Meets Centrosome: Understanding the Emerging Role of Centrosome in Controlling Inflammasome Activation
title_full Inflammasome Meets Centrosome: Understanding the Emerging Role of Centrosome in Controlling Inflammasome Activation
title_fullStr Inflammasome Meets Centrosome: Understanding the Emerging Role of Centrosome in Controlling Inflammasome Activation
title_full_unstemmed Inflammasome Meets Centrosome: Understanding the Emerging Role of Centrosome in Controlling Inflammasome Activation
title_short Inflammasome Meets Centrosome: Understanding the Emerging Role of Centrosome in Controlling Inflammasome Activation
title_sort inflammasome meets centrosome: understanding the emerging role of centrosome in controlling inflammasome activation
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907152/
https://www.ncbi.nlm.nih.gov/pubmed/35281071
http://dx.doi.org/10.3389/fimmu.2022.826106
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