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Genetic association of IL17 and the importance of ABO blood group antigens in saliva to COVID-19

The outbreak of COVID-19 caused by infection with SARS-CoV-2 virus has become a worldwide pandemic, and the number of patients presenting with respiratory failure is rapidly increasing in Japan. An international meta-analysis has been conducted to identify genetic factors associated with the onset a...

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Autores principales: Nishida, Nao, Sugiyama, Masaya, Kawai, Yosuke, Naka, Izumi, Iwamoto, Noriko, Suzuki, Tetsuya, Suzuki, Michiyo, Miyazato, Yusuke, Suzuki, Satoshi, Izumi, Shinyu, Hojo, Masayuki, Tsuchiura, Takayo, Ishikawa, Miyuki, Ohashi, Jun, Ohmagari, Norio, Tokunaga, Katsushi, Mizokami, Masashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907215/
https://www.ncbi.nlm.nih.gov/pubmed/35264675
http://dx.doi.org/10.1038/s41598-022-07856-3
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author Nishida, Nao
Sugiyama, Masaya
Kawai, Yosuke
Naka, Izumi
Iwamoto, Noriko
Suzuki, Tetsuya
Suzuki, Michiyo
Miyazato, Yusuke
Suzuki, Satoshi
Izumi, Shinyu
Hojo, Masayuki
Tsuchiura, Takayo
Ishikawa, Miyuki
Ohashi, Jun
Ohmagari, Norio
Tokunaga, Katsushi
Mizokami, Masashi
author_facet Nishida, Nao
Sugiyama, Masaya
Kawai, Yosuke
Naka, Izumi
Iwamoto, Noriko
Suzuki, Tetsuya
Suzuki, Michiyo
Miyazato, Yusuke
Suzuki, Satoshi
Izumi, Shinyu
Hojo, Masayuki
Tsuchiura, Takayo
Ishikawa, Miyuki
Ohashi, Jun
Ohmagari, Norio
Tokunaga, Katsushi
Mizokami, Masashi
author_sort Nishida, Nao
collection PubMed
description The outbreak of COVID-19 caused by infection with SARS-CoV-2 virus has become a worldwide pandemic, and the number of patients presenting with respiratory failure is rapidly increasing in Japan. An international meta-analysis has been conducted to identify genetic factors associated with the onset and severity of COVID-19, but these factors have yet to be fully clarified. Here, we carried out genomic analysis based on a genome-wide association study (GWAS) in Japanese COVID-19 patients to determine whether genetic factors reported to be associated with the onset or severity of COVID-19 in the international meta-GWAS are replicated in the Japanese population, and whether new genetic factors exist. Although no significant genome-wide association was detected in the Japanese GWAS, an integrated analysis with the international meta-GWAS identified for the first time the involvement of the IL17A/IL17F gene in the severity of COVID-19. Among nine genes reported in the international meta-GWAS as genes involved in the onset of COVID-19, the association of FOXP4-AS1, ABO, and IFNAR2 genes was replicated in the Japanese population. Moreover, combined analysis of ABO and FUT2 genotypes revealed that the presence of oral AB antigens was significantly associated with the onset of COVID-19. FOXP4-AS1 and IFNAR2 were also significantly associated in the integrated analysis of the Japanese GWAS and international meta-GWAS when compared with severe COVID-19 cases and the general population. This made it clear that these two genes were also involved in not only the onset but also the severity of COVID-19. In particular, FOXP4-AS1 was not found to be associated with the severity of COVID-19 in the international meta-GWAS, but an integrated analysis with the Japanese GWAS revealed an association with severity. Individuals with the SNP risk allele found between IL17A and IL17F had significantly lower mRNA expression levels of IL17F, suggesting that activation of the innate immune response by IL17F may play an important role in the severity of SARS-CoV-2 infection.
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spelling pubmed-89072152022-03-10 Genetic association of IL17 and the importance of ABO blood group antigens in saliva to COVID-19 Nishida, Nao Sugiyama, Masaya Kawai, Yosuke Naka, Izumi Iwamoto, Noriko Suzuki, Tetsuya Suzuki, Michiyo Miyazato, Yusuke Suzuki, Satoshi Izumi, Shinyu Hojo, Masayuki Tsuchiura, Takayo Ishikawa, Miyuki Ohashi, Jun Ohmagari, Norio Tokunaga, Katsushi Mizokami, Masashi Sci Rep Article The outbreak of COVID-19 caused by infection with SARS-CoV-2 virus has become a worldwide pandemic, and the number of patients presenting with respiratory failure is rapidly increasing in Japan. An international meta-analysis has been conducted to identify genetic factors associated with the onset and severity of COVID-19, but these factors have yet to be fully clarified. Here, we carried out genomic analysis based on a genome-wide association study (GWAS) in Japanese COVID-19 patients to determine whether genetic factors reported to be associated with the onset or severity of COVID-19 in the international meta-GWAS are replicated in the Japanese population, and whether new genetic factors exist. Although no significant genome-wide association was detected in the Japanese GWAS, an integrated analysis with the international meta-GWAS identified for the first time the involvement of the IL17A/IL17F gene in the severity of COVID-19. Among nine genes reported in the international meta-GWAS as genes involved in the onset of COVID-19, the association of FOXP4-AS1, ABO, and IFNAR2 genes was replicated in the Japanese population. Moreover, combined analysis of ABO and FUT2 genotypes revealed that the presence of oral AB antigens was significantly associated with the onset of COVID-19. FOXP4-AS1 and IFNAR2 were also significantly associated in the integrated analysis of the Japanese GWAS and international meta-GWAS when compared with severe COVID-19 cases and the general population. This made it clear that these two genes were also involved in not only the onset but also the severity of COVID-19. In particular, FOXP4-AS1 was not found to be associated with the severity of COVID-19 in the international meta-GWAS, but an integrated analysis with the Japanese GWAS revealed an association with severity. Individuals with the SNP risk allele found between IL17A and IL17F had significantly lower mRNA expression levels of IL17F, suggesting that activation of the innate immune response by IL17F may play an important role in the severity of SARS-CoV-2 infection. Nature Publishing Group UK 2022-03-09 /pmc/articles/PMC8907215/ /pubmed/35264675 http://dx.doi.org/10.1038/s41598-022-07856-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Nishida, Nao
Sugiyama, Masaya
Kawai, Yosuke
Naka, Izumi
Iwamoto, Noriko
Suzuki, Tetsuya
Suzuki, Michiyo
Miyazato, Yusuke
Suzuki, Satoshi
Izumi, Shinyu
Hojo, Masayuki
Tsuchiura, Takayo
Ishikawa, Miyuki
Ohashi, Jun
Ohmagari, Norio
Tokunaga, Katsushi
Mizokami, Masashi
Genetic association of IL17 and the importance of ABO blood group antigens in saliva to COVID-19
title Genetic association of IL17 and the importance of ABO blood group antigens in saliva to COVID-19
title_full Genetic association of IL17 and the importance of ABO blood group antigens in saliva to COVID-19
title_fullStr Genetic association of IL17 and the importance of ABO blood group antigens in saliva to COVID-19
title_full_unstemmed Genetic association of IL17 and the importance of ABO blood group antigens in saliva to COVID-19
title_short Genetic association of IL17 and the importance of ABO blood group antigens in saliva to COVID-19
title_sort genetic association of il17 and the importance of abo blood group antigens in saliva to covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907215/
https://www.ncbi.nlm.nih.gov/pubmed/35264675
http://dx.doi.org/10.1038/s41598-022-07856-3
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