Regulatory network-based model to simulate the biochemical regulation of chondrocytes in healthy and osteoarthritic environments

In osteoarthritis (OA), chondrocyte metabolism dysregulation increases relative catabolic activity, which leads to cartilage degradation. To enable the semiquantitative interpretation of the intricate mechanisms of OA progression, we propose a network-based model at the chondrocyte level that incorp...

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Detalles Bibliográficos
Autores principales: Segarra-Queralt, Maria, Neidlin, Michael, Tio, Laura, Monfort, Jordi, Monllau, Joan Carles, González Ballester, Miguel Á., Alexopoulos, Leonidas G., Piella, Gemma, Noailly, Jérôme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907219/
https://www.ncbi.nlm.nih.gov/pubmed/35264634
http://dx.doi.org/10.1038/s41598-022-07776-2

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