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Genomic evolution and adaptation of arthropod-associated Rickettsia

Rickettsia species are endosymbionts hosted by arthropods and are known to cause mild to fatal diseases in humans. Here, we analyse the evolution and diversity of 34 Rickettsia species using a pangenomic meta-analysis (80 genomes/41 plasmids). Phylogenomic trees showed that Rickettsia spp. diverged...

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Autores principales: El Karkouri, Khalid, Ghigo, Eric, Raoult, Didier, Fournier, Pierre-Edouard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907221/
https://www.ncbi.nlm.nih.gov/pubmed/35264613
http://dx.doi.org/10.1038/s41598-022-07725-z
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author El Karkouri, Khalid
Ghigo, Eric
Raoult, Didier
Fournier, Pierre-Edouard
author_facet El Karkouri, Khalid
Ghigo, Eric
Raoult, Didier
Fournier, Pierre-Edouard
author_sort El Karkouri, Khalid
collection PubMed
description Rickettsia species are endosymbionts hosted by arthropods and are known to cause mild to fatal diseases in humans. Here, we analyse the evolution and diversity of 34 Rickettsia species using a pangenomic meta-analysis (80 genomes/41 plasmids). Phylogenomic trees showed that Rickettsia spp. diverged into two Spotted Fever groups, a Typhus group, a Canadensis group and a Bellii group, and may have inherited their plasmids from an ancestral plasmid that persisted in some strains or may have been lost by others. The results suggested that the ancestors of Rickettsia spp. might have infected Acari and/or Insecta and probably diverged by persisting inside and/or switching hosts. Pangenomic analysis revealed that the Rickettsia genus evolved through a strong interplay between genome degradation/reduction and/or expansion leading to possible distinct adaptive trajectories. The genus mainly shared evolutionary relationships with α-proteobacteria, and also with γ/β/δ-proteobacteria, cytophagia, actinobacteria, cyanobacteria, chlamydiia and viruses, suggesting lateral exchanges of several critical genes. These evolutionary processes have probably been orchestrated by an abundance of mobile genetic elements, especially in the Spotted Fever and Bellii groups. In this study, we provided a global evolutionary genomic view of the intracellular Rickettsia that may help our understanding of their diversity, adaptation and fitness.
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spelling pubmed-89072212022-03-10 Genomic evolution and adaptation of arthropod-associated Rickettsia El Karkouri, Khalid Ghigo, Eric Raoult, Didier Fournier, Pierre-Edouard Sci Rep Article Rickettsia species are endosymbionts hosted by arthropods and are known to cause mild to fatal diseases in humans. Here, we analyse the evolution and diversity of 34 Rickettsia species using a pangenomic meta-analysis (80 genomes/41 plasmids). Phylogenomic trees showed that Rickettsia spp. diverged into two Spotted Fever groups, a Typhus group, a Canadensis group and a Bellii group, and may have inherited their plasmids from an ancestral plasmid that persisted in some strains or may have been lost by others. The results suggested that the ancestors of Rickettsia spp. might have infected Acari and/or Insecta and probably diverged by persisting inside and/or switching hosts. Pangenomic analysis revealed that the Rickettsia genus evolved through a strong interplay between genome degradation/reduction and/or expansion leading to possible distinct adaptive trajectories. The genus mainly shared evolutionary relationships with α-proteobacteria, and also with γ/β/δ-proteobacteria, cytophagia, actinobacteria, cyanobacteria, chlamydiia and viruses, suggesting lateral exchanges of several critical genes. These evolutionary processes have probably been orchestrated by an abundance of mobile genetic elements, especially in the Spotted Fever and Bellii groups. In this study, we provided a global evolutionary genomic view of the intracellular Rickettsia that may help our understanding of their diversity, adaptation and fitness. Nature Publishing Group UK 2022-03-09 /pmc/articles/PMC8907221/ /pubmed/35264613 http://dx.doi.org/10.1038/s41598-022-07725-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
El Karkouri, Khalid
Ghigo, Eric
Raoult, Didier
Fournier, Pierre-Edouard
Genomic evolution and adaptation of arthropod-associated Rickettsia
title Genomic evolution and adaptation of arthropod-associated Rickettsia
title_full Genomic evolution and adaptation of arthropod-associated Rickettsia
title_fullStr Genomic evolution and adaptation of arthropod-associated Rickettsia
title_full_unstemmed Genomic evolution and adaptation of arthropod-associated Rickettsia
title_short Genomic evolution and adaptation of arthropod-associated Rickettsia
title_sort genomic evolution and adaptation of arthropod-associated rickettsia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907221/
https://www.ncbi.nlm.nih.gov/pubmed/35264613
http://dx.doi.org/10.1038/s41598-022-07725-z
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