Transcellular propagation of fibrillar α-synuclein from enteroendocrine to neuronal cells requires cell-to-cell contact and is Rab35-dependent

Parkinson’s disease (PD) is a neurodegenerative condition featured by motor dysfunction, death of midbrain dopaminergic neurons and accumulation of α-synuclein (αSyn) aggregates. Growing evidence suggests that PD diagnosis happens late in the disease progression and that the pathology may originate...

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Detalles Bibliográficos
Autores principales: Rodrigues, Paulla Vieira, de Godoy, João Vitor Pereira, Bosque, Beatriz Pelegrini, Amorim Neto, Dionísio Pedro, Tostes, Katiane, Palameta, Soledad, Garcia-Rosa, Sheila, Tonoli, Celisa Caldana Costa, de Carvalho, Hernandes Faustino, de Castro Fonseca, Matheus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907230/
https://www.ncbi.nlm.nih.gov/pubmed/35264710
http://dx.doi.org/10.1038/s41598-022-08076-5

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