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Identification of multiple TAR DNA binding protein retropseudogene lineages during the evolution of primates

The TAR DNA Binding Protein (TARDBP) gene has become relevant after the discovery of its several pathogenic mutations. The lack of evolutionary history is in contrast to the amount of studies found in the literature. This study investigated the evolutionary dynamics associated with the retrotranspos...

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Autores principales: Opazo, Juan C., Zavala, Kattina, Vargas-Chacoff, Luis, Morera, Francisco J., Mardones, Gonzalo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907276/
https://www.ncbi.nlm.nih.gov/pubmed/35264686
http://dx.doi.org/10.1038/s41598-022-07908-8
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author Opazo, Juan C.
Zavala, Kattina
Vargas-Chacoff, Luis
Morera, Francisco J.
Mardones, Gonzalo A.
author_facet Opazo, Juan C.
Zavala, Kattina
Vargas-Chacoff, Luis
Morera, Francisco J.
Mardones, Gonzalo A.
author_sort Opazo, Juan C.
collection PubMed
description The TAR DNA Binding Protein (TARDBP) gene has become relevant after the discovery of its several pathogenic mutations. The lack of evolutionary history is in contrast to the amount of studies found in the literature. This study investigated the evolutionary dynamics associated with the retrotransposition of the TARDBP gene in primates. We identified novel retropseudogenes that likely originated in the ancestors of anthropoids, catarrhines, and lemuriformes, i.e. the strepsirrhine clade that inhabit Madagascar. We also found species-specific retropseudogenes in the Philippine tarsier, Bolivian squirrel monkey, capuchin monkey and vervet. The identification of a retropseudocopy of the TARDBP gene overlapping a lncRNA that is potentially expressed opens a new avenue to investigate TARDBP gene regulation, especially in the context of TARDBP associated pathologies.
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spelling pubmed-89072762022-03-11 Identification of multiple TAR DNA binding protein retropseudogene lineages during the evolution of primates Opazo, Juan C. Zavala, Kattina Vargas-Chacoff, Luis Morera, Francisco J. Mardones, Gonzalo A. Sci Rep Article The TAR DNA Binding Protein (TARDBP) gene has become relevant after the discovery of its several pathogenic mutations. The lack of evolutionary history is in contrast to the amount of studies found in the literature. This study investigated the evolutionary dynamics associated with the retrotransposition of the TARDBP gene in primates. We identified novel retropseudogenes that likely originated in the ancestors of anthropoids, catarrhines, and lemuriformes, i.e. the strepsirrhine clade that inhabit Madagascar. We also found species-specific retropseudogenes in the Philippine tarsier, Bolivian squirrel monkey, capuchin monkey and vervet. The identification of a retropseudocopy of the TARDBP gene overlapping a lncRNA that is potentially expressed opens a new avenue to investigate TARDBP gene regulation, especially in the context of TARDBP associated pathologies. Nature Publishing Group UK 2022-03-09 /pmc/articles/PMC8907276/ /pubmed/35264686 http://dx.doi.org/10.1038/s41598-022-07908-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Opazo, Juan C.
Zavala, Kattina
Vargas-Chacoff, Luis
Morera, Francisco J.
Mardones, Gonzalo A.
Identification of multiple TAR DNA binding protein retropseudogene lineages during the evolution of primates
title Identification of multiple TAR DNA binding protein retropseudogene lineages during the evolution of primates
title_full Identification of multiple TAR DNA binding protein retropseudogene lineages during the evolution of primates
title_fullStr Identification of multiple TAR DNA binding protein retropseudogene lineages during the evolution of primates
title_full_unstemmed Identification of multiple TAR DNA binding protein retropseudogene lineages during the evolution of primates
title_short Identification of multiple TAR DNA binding protein retropseudogene lineages during the evolution of primates
title_sort identification of multiple tar dna binding protein retropseudogene lineages during the evolution of primates
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907276/
https://www.ncbi.nlm.nih.gov/pubmed/35264686
http://dx.doi.org/10.1038/s41598-022-07908-8
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