Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus

Many individual genetic risk loci have been associated with multiple common human diseases. However, the molecular basis of this pleiotropy often remains unclear. We present an integrative approach to reveal the molecular mechanism underlying the PROCR locus, associated with lower coronary artery di...

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Detalles Bibliográficos
Autores principales: Stacey, David, Chen, Lingyan, Stanczyk, Paulina J., Howson, Joanna M. M., Mason, Amy M., Burgess, Stephen, MacDonald, Stephen, Langdown, Jonathan, McKinney, Harriett, Downes, Kate, Farahi, Neda, Peters, James E., Basu, Saonli, Pankow, James S., Tang, Weihong, Pankratz, Nathan, Sabater-Lleal, Maria, de Vries, Paul S., Smith, Nicholas L., Gelinas, Amy D., Schneider, Daniel J., Janjic, Nebojsa, Samani, Nilesh J., Ye, Shu, Summers, Charlotte, Chilvers, Edwin R., Danesh, John, Paul, Dirk S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907312/
https://www.ncbi.nlm.nih.gov/pubmed/35264566
http://dx.doi.org/10.1038/s41467-022-28729-3

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