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Antidiabetic Phytochemicals From Medicinal Plants: Prospective Candidates for New Drug Discovery and Development
Diabetes, a chronic physiological dysfunction affecting people of different age groups and severely impairs the harmony of peoples’ normal life worldwide. Despite the availability of insulin preparations and several synthetic oral antidiabetic drugs, there is a crucial need for the discovery and dev...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907382/ https://www.ncbi.nlm.nih.gov/pubmed/35282429 http://dx.doi.org/10.3389/fendo.2022.800714 |
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author | Alam, Safaet Sarker, Md. Moklesur Rahman Sultana, Taposhi Nahid Chowdhury, Md. Nafees Rahman Rashid, Mohammad A. Chaity, Nusrat Islam Zhao, Chao Xiao, Jianbo Hafez, Elsayed E. Khan, Shah Alam Mohamed, Isa Naina |
author_facet | Alam, Safaet Sarker, Md. Moklesur Rahman Sultana, Taposhi Nahid Chowdhury, Md. Nafees Rahman Rashid, Mohammad A. Chaity, Nusrat Islam Zhao, Chao Xiao, Jianbo Hafez, Elsayed E. Khan, Shah Alam Mohamed, Isa Naina |
author_sort | Alam, Safaet |
collection | PubMed |
description | Diabetes, a chronic physiological dysfunction affecting people of different age groups and severely impairs the harmony of peoples’ normal life worldwide. Despite the availability of insulin preparations and several synthetic oral antidiabetic drugs, there is a crucial need for the discovery and development of novel antidiabetic drugs because of the development of resistance and side effects of those drugs in long-term use. On the contrary, plants or herbal sources are getting popular day by day to the scientists, researchers, and pharmaceutical companies all over the world to search for potential bioactive compound(s) for the discovery and development of targeted novel antidiabetic drugs that may control diabetes with the least unwanted effects of conventional antidiabetic drugs. In this review, we have presented the prospective candidates comprised of either isolated phytochemical(s) and/or extract(s) containing bioactive phytoconstituents which have been reported in several in vitro, in vivo, and clinical studies possessing noteworthy antidiabetic potential. The mode of actions, attributed to antidiabetic activities of the reported phytochemicals and/or plant extracts have also been described to focus on the prospective phytochemicals and phytosources for further studies in the discovery and development of novel antidiabetic therapeutics. |
format | Online Article Text |
id | pubmed-8907382 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-89073822022-03-11 Antidiabetic Phytochemicals From Medicinal Plants: Prospective Candidates for New Drug Discovery and Development Alam, Safaet Sarker, Md. Moklesur Rahman Sultana, Taposhi Nahid Chowdhury, Md. Nafees Rahman Rashid, Mohammad A. Chaity, Nusrat Islam Zhao, Chao Xiao, Jianbo Hafez, Elsayed E. Khan, Shah Alam Mohamed, Isa Naina Front Endocrinol (Lausanne) Endocrinology Diabetes, a chronic physiological dysfunction affecting people of different age groups and severely impairs the harmony of peoples’ normal life worldwide. Despite the availability of insulin preparations and several synthetic oral antidiabetic drugs, there is a crucial need for the discovery and development of novel antidiabetic drugs because of the development of resistance and side effects of those drugs in long-term use. On the contrary, plants or herbal sources are getting popular day by day to the scientists, researchers, and pharmaceutical companies all over the world to search for potential bioactive compound(s) for the discovery and development of targeted novel antidiabetic drugs that may control diabetes with the least unwanted effects of conventional antidiabetic drugs. In this review, we have presented the prospective candidates comprised of either isolated phytochemical(s) and/or extract(s) containing bioactive phytoconstituents which have been reported in several in vitro, in vivo, and clinical studies possessing noteworthy antidiabetic potential. The mode of actions, attributed to antidiabetic activities of the reported phytochemicals and/or plant extracts have also been described to focus on the prospective phytochemicals and phytosources for further studies in the discovery and development of novel antidiabetic therapeutics. Frontiers Media S.A. 2022-02-24 /pmc/articles/PMC8907382/ /pubmed/35282429 http://dx.doi.org/10.3389/fendo.2022.800714 Text en Copyright © 2022 Alam, Sarker, Sultana, Chowdhury, Rashid, Chaity, Zhao, Xiao, Hafez, Khan and Mohamed https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Alam, Safaet Sarker, Md. Moklesur Rahman Sultana, Taposhi Nahid Chowdhury, Md. Nafees Rahman Rashid, Mohammad A. Chaity, Nusrat Islam Zhao, Chao Xiao, Jianbo Hafez, Elsayed E. Khan, Shah Alam Mohamed, Isa Naina Antidiabetic Phytochemicals From Medicinal Plants: Prospective Candidates for New Drug Discovery and Development |
title | Antidiabetic Phytochemicals From Medicinal Plants: Prospective Candidates for New Drug Discovery and Development |
title_full | Antidiabetic Phytochemicals From Medicinal Plants: Prospective Candidates for New Drug Discovery and Development |
title_fullStr | Antidiabetic Phytochemicals From Medicinal Plants: Prospective Candidates for New Drug Discovery and Development |
title_full_unstemmed | Antidiabetic Phytochemicals From Medicinal Plants: Prospective Candidates for New Drug Discovery and Development |
title_short | Antidiabetic Phytochemicals From Medicinal Plants: Prospective Candidates for New Drug Discovery and Development |
title_sort | antidiabetic phytochemicals from medicinal plants: prospective candidates for new drug discovery and development |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907382/ https://www.ncbi.nlm.nih.gov/pubmed/35282429 http://dx.doi.org/10.3389/fendo.2022.800714 |
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