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Suppression of Neuroinflammation Attenuates Persistent Cognitive and Neurogenic Deficits in a Rat Model of Cardiopulmonary Bypass

Post-operative cognitive dysfunction (POCD) can be a serious surgical complication, and patients undergoing cardiac procedures are at particular risk for POCD. This study examined the effect of blocking neuroinflammation on behavioral and neurogenic deficits produced in a rat model of cardiopulmonar...

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Autores principales: Wang, Yi, Machizawa, Maro G., Lisle, Turner, Williams, Cedric L., Clarke, Ryon, Anzivino, Matthew, Kron, Irving, Lee, Kevin S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907423/
https://www.ncbi.nlm.nih.gov/pubmed/35281295
http://dx.doi.org/10.3389/fncel.2022.780880
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author Wang, Yi
Machizawa, Maro G.
Lisle, Turner
Williams, Cedric L.
Clarke, Ryon
Anzivino, Matthew
Kron, Irving
Lee, Kevin S.
author_facet Wang, Yi
Machizawa, Maro G.
Lisle, Turner
Williams, Cedric L.
Clarke, Ryon
Anzivino, Matthew
Kron, Irving
Lee, Kevin S.
author_sort Wang, Yi
collection PubMed
description Post-operative cognitive dysfunction (POCD) can be a serious surgical complication, and patients undergoing cardiac procedures are at particular risk for POCD. This study examined the effect of blocking neuroinflammation on behavioral and neurogenic deficits produced in a rat model of cardiopulmonary bypass (CPB). Minocycline, a drug with established anti-inflammatory activity, or saline was administered daily for 30 days post-CPB. Treatment with minocycline reduced the number of activated microglia/macrophages observed in the dentate gyrus of the hippocampus at 6 months post-CPB, consistent with an anti-inflammatory action in this CPB model. Behavioral testing was conducted at 6 months post-CPB utilizing a win-shift task on an 8-arm radial maze. Minocycline-treated animals performed significantly better than saline-treated animals on this task after CPB. In addition, the CPB-induced reduction in adult neurogenesis was attenuated in the minocycline-treated animals. Together, these findings indicate that suppressing neuroinflammation during the early post-surgical phase can limit long-term deficits in both behavioral and neurogenic outcomes after CPB.
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spelling pubmed-89074232022-03-11 Suppression of Neuroinflammation Attenuates Persistent Cognitive and Neurogenic Deficits in a Rat Model of Cardiopulmonary Bypass Wang, Yi Machizawa, Maro G. Lisle, Turner Williams, Cedric L. Clarke, Ryon Anzivino, Matthew Kron, Irving Lee, Kevin S. Front Cell Neurosci Neuroscience Post-operative cognitive dysfunction (POCD) can be a serious surgical complication, and patients undergoing cardiac procedures are at particular risk for POCD. This study examined the effect of blocking neuroinflammation on behavioral and neurogenic deficits produced in a rat model of cardiopulmonary bypass (CPB). Minocycline, a drug with established anti-inflammatory activity, or saline was administered daily for 30 days post-CPB. Treatment with minocycline reduced the number of activated microglia/macrophages observed in the dentate gyrus of the hippocampus at 6 months post-CPB, consistent with an anti-inflammatory action in this CPB model. Behavioral testing was conducted at 6 months post-CPB utilizing a win-shift task on an 8-arm radial maze. Minocycline-treated animals performed significantly better than saline-treated animals on this task after CPB. In addition, the CPB-induced reduction in adult neurogenesis was attenuated in the minocycline-treated animals. Together, these findings indicate that suppressing neuroinflammation during the early post-surgical phase can limit long-term deficits in both behavioral and neurogenic outcomes after CPB. Frontiers Media S.A. 2022-02-24 /pmc/articles/PMC8907423/ /pubmed/35281295 http://dx.doi.org/10.3389/fncel.2022.780880 Text en Copyright © 2022 Wang, Machizawa, Lisle, Williams, Clarke, Anzivino, Kron and Lee. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Wang, Yi
Machizawa, Maro G.
Lisle, Turner
Williams, Cedric L.
Clarke, Ryon
Anzivino, Matthew
Kron, Irving
Lee, Kevin S.
Suppression of Neuroinflammation Attenuates Persistent Cognitive and Neurogenic Deficits in a Rat Model of Cardiopulmonary Bypass
title Suppression of Neuroinflammation Attenuates Persistent Cognitive and Neurogenic Deficits in a Rat Model of Cardiopulmonary Bypass
title_full Suppression of Neuroinflammation Attenuates Persistent Cognitive and Neurogenic Deficits in a Rat Model of Cardiopulmonary Bypass
title_fullStr Suppression of Neuroinflammation Attenuates Persistent Cognitive and Neurogenic Deficits in a Rat Model of Cardiopulmonary Bypass
title_full_unstemmed Suppression of Neuroinflammation Attenuates Persistent Cognitive and Neurogenic Deficits in a Rat Model of Cardiopulmonary Bypass
title_short Suppression of Neuroinflammation Attenuates Persistent Cognitive and Neurogenic Deficits in a Rat Model of Cardiopulmonary Bypass
title_sort suppression of neuroinflammation attenuates persistent cognitive and neurogenic deficits in a rat model of cardiopulmonary bypass
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907423/
https://www.ncbi.nlm.nih.gov/pubmed/35281295
http://dx.doi.org/10.3389/fncel.2022.780880
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