2-Alkylation of 3-Alkyindoles With Unactivated Alkenes

An acid-catalyzed 2-alkylation of indole molecules is developed. Only catalytic amount of the commercially available, inexpensive and traceless HI is used as the sole reaction promoter. 2,3-Disubstituted indole molecules bearing congested tertiary carbon centers are afforded as the final products in...

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Detalles Bibliográficos
Autores principales: Pan, Xuling, Liu, Qian, Nong, Yingling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907451/
https://www.ncbi.nlm.nih.gov/pubmed/35281568
http://dx.doi.org/10.3389/fchem.2022.860764
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author Pan, Xuling
Liu, Qian
Nong, Yingling
author_facet Pan, Xuling
Liu, Qian
Nong, Yingling
author_sort Pan, Xuling
collection PubMed
description An acid-catalyzed 2-alkylation of indole molecules is developed. Only catalytic amount of the commercially available, inexpensive and traceless HI is used as the sole reaction promoter. 2,3-Disubstituted indole molecules bearing congested tertiary carbon centers are afforded as the final products in moderate to excellent yields.
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spelling pubmed-89074512022-03-11 2-Alkylation of 3-Alkyindoles With Unactivated Alkenes Pan, Xuling Liu, Qian Nong, Yingling Front Chem Chemistry An acid-catalyzed 2-alkylation of indole molecules is developed. Only catalytic amount of the commercially available, inexpensive and traceless HI is used as the sole reaction promoter. 2,3-Disubstituted indole molecules bearing congested tertiary carbon centers are afforded as the final products in moderate to excellent yields. Frontiers Media S.A. 2022-02-24 /pmc/articles/PMC8907451/ /pubmed/35281568 http://dx.doi.org/10.3389/fchem.2022.860764 Text en Copyright © 2022 Pan, Liu and Nong. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Pan, Xuling
Liu, Qian
Nong, Yingling
2-Alkylation of 3-Alkyindoles With Unactivated Alkenes
title 2-Alkylation of 3-Alkyindoles With Unactivated Alkenes
title_full 2-Alkylation of 3-Alkyindoles With Unactivated Alkenes
title_fullStr 2-Alkylation of 3-Alkyindoles With Unactivated Alkenes
title_full_unstemmed 2-Alkylation of 3-Alkyindoles With Unactivated Alkenes
title_short 2-Alkylation of 3-Alkyindoles With Unactivated Alkenes
title_sort 2-alkylation of 3-alkyindoles with unactivated alkenes
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907451/
https://www.ncbi.nlm.nih.gov/pubmed/35281568
http://dx.doi.org/10.3389/fchem.2022.860764
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AT liuqian 2alkylationof3alkyindoleswithunactivatedalkenes
AT nongyingling 2alkylationof3alkyindoleswithunactivatedalkenes

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