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Evaluation of ABT-888 in the amelioration of α-synuclein fibril-induced neurodegeneration

The accumulation of α-synuclein inclusions in vulnerable neuronal populations pathologically defines Lewy body diseases including Parkinson’s disease. Recent pre-clinical studies suggest poly(ADP-ribose) polymerase-1 activation and the subsequent generation of poly(ADP-ribose) polymer represent key...

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Detalles Bibliográficos
Autores principales:	Hastings, Lyndsay, Sokratian, Arpine, Apicco, Daniel J., Stanhope, Christina M., Smith, Lindsey, Hirst, Warren D., West, Andrew B., Kelly, Kaela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907490/ https://www.ncbi.nlm.nih.gov/pubmed/35282165 http://dx.doi.org/10.1093/braincomms/fcac042

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