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Microbiome Resilience and Health Implications for People in Half-Year Travel

Travel entail change in geography and diet, both of which are known as determinant factors in shaping the human gut microbiome. Additionally, altered gut microbiome modulates immunity, bringing about health implications in humans. To explore the effects of the mid-term travel on the gut microbiome,...

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Autores principales: Cheng, Mingyue, Liu, Hong, Han, Maozhen, Li, Shuai Cheng, Bu, Dongbo, Sun, Shiwei, Hu, Zhiqiang, Yang, Pengshuo, Wang, Rui, Liu, Yawen, Chen, Feng, Peng, Jianjun, Peng, Hong, Song, Hongxing, Xia, Yang, Chu, Liqun, Zhou, Quan, Guan, Feng, Wu, Jing, Tan, Guangming, Ning, Kang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907539/
https://www.ncbi.nlm.nih.gov/pubmed/35281043
http://dx.doi.org/10.3389/fimmu.2022.848994
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author Cheng, Mingyue
Liu, Hong
Han, Maozhen
Li, Shuai Cheng
Bu, Dongbo
Sun, Shiwei
Hu, Zhiqiang
Yang, Pengshuo
Wang, Rui
Liu, Yawen
Chen, Feng
Peng, Jianjun
Peng, Hong
Song, Hongxing
Xia, Yang
Chu, Liqun
Zhou, Quan
Guan, Feng
Wu, Jing
Tan, Guangming
Ning, Kang
author_facet Cheng, Mingyue
Liu, Hong
Han, Maozhen
Li, Shuai Cheng
Bu, Dongbo
Sun, Shiwei
Hu, Zhiqiang
Yang, Pengshuo
Wang, Rui
Liu, Yawen
Chen, Feng
Peng, Jianjun
Peng, Hong
Song, Hongxing
Xia, Yang
Chu, Liqun
Zhou, Quan
Guan, Feng
Wu, Jing
Tan, Guangming
Ning, Kang
author_sort Cheng, Mingyue
collection PubMed
description Travel entail change in geography and diet, both of which are known as determinant factors in shaping the human gut microbiome. Additionally, altered gut microbiome modulates immunity, bringing about health implications in humans. To explore the effects of the mid-term travel on the gut microbiome, we generated 16S rRNA gene and metagenomic sequencing data from longitudinal samples collected over six months. We monitored dynamic trajectories of the gut microbiome variation of a Chinese volunteer team (VT) in their whole journey to Trinidad and Tobago (TAT). We found gut microbiome resilience that VT’s gut microbial compositions gradually transformed to the local TAT’s enterotypes during their six-month stay in TAT, and then reverted to their original enterotypes after VT’s return to Beijing in one month. Moreover, we identified driven species in this bi-directional plasticity that could play a role in immunity modulation, as exemplified by Bacteroides dorei that attenuated atherosclerotic lesion formation and effectively suppressed proinflammatory immune response. Another driven species P. copri could play a crucial role in rheumatoid arthritis pathogenesis, a chronic autoimmune disease. Carbohydrate-active enzymes are often implicated in immune and host-pathogen interactions, of which glycoside hydrolases were found decreased but glycosyltransferases and carbohydrate esterases increased during the travel; these functions were then restored after VT’ returning to Beijing. Furthermore, we discovered these microbial changes and restoration were mediated by VT people’s dietary changes. These findings indicate that half-year travel leads to change in enterotype and functional patterns, exerting effects on human health. Microbial intervention by dietary guidance in half-year travel would be conducive to immunity modulation for maintaining health.
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spelling pubmed-89075392022-03-11 Microbiome Resilience and Health Implications for People in Half-Year Travel Cheng, Mingyue Liu, Hong Han, Maozhen Li, Shuai Cheng Bu, Dongbo Sun, Shiwei Hu, Zhiqiang Yang, Pengshuo Wang, Rui Liu, Yawen Chen, Feng Peng, Jianjun Peng, Hong Song, Hongxing Xia, Yang Chu, Liqun Zhou, Quan Guan, Feng Wu, Jing Tan, Guangming Ning, Kang Front Immunol Immunology Travel entail change in geography and diet, both of which are known as determinant factors in shaping the human gut microbiome. Additionally, altered gut microbiome modulates immunity, bringing about health implications in humans. To explore the effects of the mid-term travel on the gut microbiome, we generated 16S rRNA gene and metagenomic sequencing data from longitudinal samples collected over six months. We monitored dynamic trajectories of the gut microbiome variation of a Chinese volunteer team (VT) in their whole journey to Trinidad and Tobago (TAT). We found gut microbiome resilience that VT’s gut microbial compositions gradually transformed to the local TAT’s enterotypes during their six-month stay in TAT, and then reverted to their original enterotypes after VT’s return to Beijing in one month. Moreover, we identified driven species in this bi-directional plasticity that could play a role in immunity modulation, as exemplified by Bacteroides dorei that attenuated atherosclerotic lesion formation and effectively suppressed proinflammatory immune response. Another driven species P. copri could play a crucial role in rheumatoid arthritis pathogenesis, a chronic autoimmune disease. Carbohydrate-active enzymes are often implicated in immune and host-pathogen interactions, of which glycoside hydrolases were found decreased but glycosyltransferases and carbohydrate esterases increased during the travel; these functions were then restored after VT’ returning to Beijing. Furthermore, we discovered these microbial changes and restoration were mediated by VT people’s dietary changes. These findings indicate that half-year travel leads to change in enterotype and functional patterns, exerting effects on human health. Microbial intervention by dietary guidance in half-year travel would be conducive to immunity modulation for maintaining health. Frontiers Media S.A. 2022-02-24 /pmc/articles/PMC8907539/ /pubmed/35281043 http://dx.doi.org/10.3389/fimmu.2022.848994 Text en Copyright © 2022 Cheng, Liu, Han, Li, Bu, Sun, Hu, Yang, Wang, Liu, Chen, Peng, Peng, Song, Xia, Chu, Zhou, Guan, Wu, Tan and Ning https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Cheng, Mingyue
Liu, Hong
Han, Maozhen
Li, Shuai Cheng
Bu, Dongbo
Sun, Shiwei
Hu, Zhiqiang
Yang, Pengshuo
Wang, Rui
Liu, Yawen
Chen, Feng
Peng, Jianjun
Peng, Hong
Song, Hongxing
Xia, Yang
Chu, Liqun
Zhou, Quan
Guan, Feng
Wu, Jing
Tan, Guangming
Ning, Kang
Microbiome Resilience and Health Implications for People in Half-Year Travel
title Microbiome Resilience and Health Implications for People in Half-Year Travel
title_full Microbiome Resilience and Health Implications for People in Half-Year Travel
title_fullStr Microbiome Resilience and Health Implications for People in Half-Year Travel
title_full_unstemmed Microbiome Resilience and Health Implications for People in Half-Year Travel
title_short Microbiome Resilience and Health Implications for People in Half-Year Travel
title_sort microbiome resilience and health implications for people in half-year travel
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907539/
https://www.ncbi.nlm.nih.gov/pubmed/35281043
http://dx.doi.org/10.3389/fimmu.2022.848994
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