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Complex Crystal Structure Determination of Hsp90(N)-NVP-AUY922 and In Vitro Anti-NSCLC Activity of NVP-AUY922

New targeted chemotherapy agents greatly improved five-year survival in NSCLC patients, but which were susceptible to drug resistance. NVP-AUY922, terminated in phase II clinical trials, exhibited promising anti-NSCLC (non-small-cell lung cancer) activity targeting to Hsp90(N) (heat shock protein),...

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Detalles Bibliográficos
Autores principales:	He, Chun-Xia, Lv, You, Guo, Meng, Zhou, Huan, Qin, Wei, Zhao, Dong, Li, Hui-Jin, Xing, Lu, Zhou, Xin, Li, Peng-Quan, Yu, Feng, He, Jian-Hua, Cao, Hui-Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907572/ https://www.ncbi.nlm.nih.gov/pubmed/35280745 http://dx.doi.org/10.3389/fonc.2022.847556

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