Cargando…

Low Intensity Focused Ultrasound for Non-invasive and Reversible Deep Brain Neuromodulation—A Paradigm Shift in Psychiatric Research

This article describes an emerging non-invasive neuromodulatory technology, called low intensity focused ultrasound (LIFU). This technology is potentially paradigm shifting as it can deliver non-invasive and reversible deep brain neuromodulation through acoustic sonication, at millimeter precision....

Descripción completa

Detalles Bibliográficos
Autores principales: Arulpragasam, Amanda R., van 't Wout-Frank, Mascha, Barredo, Jennifer, Faucher, Christiana R., Greenberg, Benjamin D., Philip, Noah S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907584/
https://www.ncbi.nlm.nih.gov/pubmed/35280168
http://dx.doi.org/10.3389/fpsyt.2022.825802
_version_ 1784665679549431808
author Arulpragasam, Amanda R.
van 't Wout-Frank, Mascha
Barredo, Jennifer
Faucher, Christiana R.
Greenberg, Benjamin D.
Philip, Noah S.
author_facet Arulpragasam, Amanda R.
van 't Wout-Frank, Mascha
Barredo, Jennifer
Faucher, Christiana R.
Greenberg, Benjamin D.
Philip, Noah S.
author_sort Arulpragasam, Amanda R.
collection PubMed
description This article describes an emerging non-invasive neuromodulatory technology, called low intensity focused ultrasound (LIFU). This technology is potentially paradigm shifting as it can deliver non-invasive and reversible deep brain neuromodulation through acoustic sonication, at millimeter precision. Low intensity focused ultrasound's spatial precision, yet non-invasive nature sets it apart from current technologies, such as transcranial magnetic or electrical stimulation and deep brain stimulation. Additionally, its reversible effects allow for the causal study of deep brain regions implicated in psychiatric illness. Studies to date have demonstrated that LIFU can safely modulate human brain activity at cortical and subcortical levels. Due to its novelty, most researchers and clinicians are not aware of the potential applications and promise of this technique, underscoring the need for foundational papers to introduce the community to LIFU. This mini-review and synthesis of recent advances examines several key papers on LIFU administered to humans, describes the population under study, parameters used, and relevant findings that may guide future research. We conclude with a concise overview of some of the more pressing questions to date, considerations when interpreting new data from an emerging field, and highlight the opportunities and challenges in this exciting new area of study.
format Online
Article
Text
id pubmed-8907584
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-89075842022-03-11 Low Intensity Focused Ultrasound for Non-invasive and Reversible Deep Brain Neuromodulation—A Paradigm Shift in Psychiatric Research Arulpragasam, Amanda R. van 't Wout-Frank, Mascha Barredo, Jennifer Faucher, Christiana R. Greenberg, Benjamin D. Philip, Noah S. Front Psychiatry Psychiatry This article describes an emerging non-invasive neuromodulatory technology, called low intensity focused ultrasound (LIFU). This technology is potentially paradigm shifting as it can deliver non-invasive and reversible deep brain neuromodulation through acoustic sonication, at millimeter precision. Low intensity focused ultrasound's spatial precision, yet non-invasive nature sets it apart from current technologies, such as transcranial magnetic or electrical stimulation and deep brain stimulation. Additionally, its reversible effects allow for the causal study of deep brain regions implicated in psychiatric illness. Studies to date have demonstrated that LIFU can safely modulate human brain activity at cortical and subcortical levels. Due to its novelty, most researchers and clinicians are not aware of the potential applications and promise of this technique, underscoring the need for foundational papers to introduce the community to LIFU. This mini-review and synthesis of recent advances examines several key papers on LIFU administered to humans, describes the population under study, parameters used, and relevant findings that may guide future research. We conclude with a concise overview of some of the more pressing questions to date, considerations when interpreting new data from an emerging field, and highlight the opportunities and challenges in this exciting new area of study. Frontiers Media S.A. 2022-02-24 /pmc/articles/PMC8907584/ /pubmed/35280168 http://dx.doi.org/10.3389/fpsyt.2022.825802 Text en Copyright © 2022 Arulpragasam, van 't Wout-Frank, Barredo, Faucher, Greenberg and Philip. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Arulpragasam, Amanda R.
van 't Wout-Frank, Mascha
Barredo, Jennifer
Faucher, Christiana R.
Greenberg, Benjamin D.
Philip, Noah S.
Low Intensity Focused Ultrasound for Non-invasive and Reversible Deep Brain Neuromodulation—A Paradigm Shift in Psychiatric Research
title Low Intensity Focused Ultrasound for Non-invasive and Reversible Deep Brain Neuromodulation—A Paradigm Shift in Psychiatric Research
title_full Low Intensity Focused Ultrasound for Non-invasive and Reversible Deep Brain Neuromodulation—A Paradigm Shift in Psychiatric Research
title_fullStr Low Intensity Focused Ultrasound for Non-invasive and Reversible Deep Brain Neuromodulation—A Paradigm Shift in Psychiatric Research
title_full_unstemmed Low Intensity Focused Ultrasound for Non-invasive and Reversible Deep Brain Neuromodulation—A Paradigm Shift in Psychiatric Research
title_short Low Intensity Focused Ultrasound for Non-invasive and Reversible Deep Brain Neuromodulation—A Paradigm Shift in Psychiatric Research
title_sort low intensity focused ultrasound for non-invasive and reversible deep brain neuromodulation—a paradigm shift in psychiatric research
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907584/
https://www.ncbi.nlm.nih.gov/pubmed/35280168
http://dx.doi.org/10.3389/fpsyt.2022.825802
work_keys_str_mv AT arulpragasamamandar lowintensityfocusedultrasoundfornoninvasiveandreversibledeepbrainneuromodulationaparadigmshiftinpsychiatricresearch
AT vantwoutfrankmascha lowintensityfocusedultrasoundfornoninvasiveandreversibledeepbrainneuromodulationaparadigmshiftinpsychiatricresearch
AT barredojennifer lowintensityfocusedultrasoundfornoninvasiveandreversibledeepbrainneuromodulationaparadigmshiftinpsychiatricresearch
AT faucherchristianar lowintensityfocusedultrasoundfornoninvasiveandreversibledeepbrainneuromodulationaparadigmshiftinpsychiatricresearch
AT greenbergbenjamind lowintensityfocusedultrasoundfornoninvasiveandreversibledeepbrainneuromodulationaparadigmshiftinpsychiatricresearch
AT philipnoahs lowintensityfocusedultrasoundfornoninvasiveandreversibledeepbrainneuromodulationaparadigmshiftinpsychiatricresearch