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Neuroendocrine Differentiated Breast Cancer Cases: A Retrospective Analysis and Literature Review

OBJECTIVES: Neuroendocrine breast carcinoma (NEBC) is a rare subgroup of breast cancer, which makes up 2–5% of all invasive breast cancers. The aim of this retrospective analysis is to present and analyze our own data of primary NEBCs. METHODS: We retrospectively analyzed clinical, pathological, and...

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Autores principales: Ozdemir, Ozlem, Zengel, Baha, Yildiz, Yasar, Saray, Seray, Alacacioglu, Ahmet, Tasli, Funda, Can Erdi, Zuleyha, Oflazoglu, Utku, Taskaynatan, Halil, Salman, Tarik, Varol, Umut, Hilal Adibelli, Zehra, Durusoy, Raika, Kucukzeybek, Yuksel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Med Bull Sisli Etfal Hosp 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907703/
https://www.ncbi.nlm.nih.gov/pubmed/35317367
http://dx.doi.org/10.14744/SEMB.2021.66503
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author Ozdemir, Ozlem
Zengel, Baha
Yildiz, Yasar
Saray, Seray
Alacacioglu, Ahmet
Tasli, Funda
Can Erdi, Zuleyha
Oflazoglu, Utku
Taskaynatan, Halil
Salman, Tarik
Varol, Umut
Hilal Adibelli, Zehra
Durusoy, Raika
Kucukzeybek, Yuksel
author_facet Ozdemir, Ozlem
Zengel, Baha
Yildiz, Yasar
Saray, Seray
Alacacioglu, Ahmet
Tasli, Funda
Can Erdi, Zuleyha
Oflazoglu, Utku
Taskaynatan, Halil
Salman, Tarik
Varol, Umut
Hilal Adibelli, Zehra
Durusoy, Raika
Kucukzeybek, Yuksel
author_sort Ozdemir, Ozlem
collection PubMed
description OBJECTIVES: Neuroendocrine breast carcinoma (NEBC) is a rare subgroup of breast cancer, which makes up 2–5% of all invasive breast cancers. The aim of this retrospective analysis is to present and analyze our own data of primary NEBCs. METHODS: We retrospectively analyzed clinical, pathological, and radiological characteristics of 36 patients diagnosed with neuroendocrine differentiated breast cancer between 2008 and 2019 compared to that of 925 patients with invasive ductal carcinoma (IDC/NOS) along with a literature review. RESULTS: In this study, 36 patients with neuroendocrine differentiated breast carcinoma and 961 patients with (IDC/NOS), as the comparison group, were identified between 2008 and 2019. In NEBC patients, seven were premenopausal and 29 postmenopausal. Patients whose ultrasound (USG), magnetic resonance, and mammographic (MMG) images available in our hospital, high-density masses were detected in the MMG with irregular (77%), microlobulated (80%) and spiculated margins (63%), unaccompanied by asymmetry and structural distortion. Calcifications were less common than invasive breast cancer, present only in four patients (17%). When NEBC were compared to ductal carcinomas (n=925), NEBC were more often human epidermal growth factor receptor 2 negative (p=0.039), estrogen receptor positive (p=0.05), progesterone receptor positive (0.03), and the NEBC patients were older (p=0.02). Age, grade, metastatic status, lymph node number, and molecular type were identified as prognostic factors that significantly affect survival in both groups (p<0.05). CONCLUSION: NEBC is a subtype that is both histopathologically and radiologically distinct from other breast cancer subtypes, and neuroendocrine differentiation may be an important predictive marker in the future.
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spelling pubmed-89077032022-03-21 Neuroendocrine Differentiated Breast Cancer Cases: A Retrospective Analysis and Literature Review Ozdemir, Ozlem Zengel, Baha Yildiz, Yasar Saray, Seray Alacacioglu, Ahmet Tasli, Funda Can Erdi, Zuleyha Oflazoglu, Utku Taskaynatan, Halil Salman, Tarik Varol, Umut Hilal Adibelli, Zehra Durusoy, Raika Kucukzeybek, Yuksel Sisli Etfal Hastan Tip Bul Original Research OBJECTIVES: Neuroendocrine breast carcinoma (NEBC) is a rare subgroup of breast cancer, which makes up 2–5% of all invasive breast cancers. The aim of this retrospective analysis is to present and analyze our own data of primary NEBCs. METHODS: We retrospectively analyzed clinical, pathological, and radiological characteristics of 36 patients diagnosed with neuroendocrine differentiated breast cancer between 2008 and 2019 compared to that of 925 patients with invasive ductal carcinoma (IDC/NOS) along with a literature review. RESULTS: In this study, 36 patients with neuroendocrine differentiated breast carcinoma and 961 patients with (IDC/NOS), as the comparison group, were identified between 2008 and 2019. In NEBC patients, seven were premenopausal and 29 postmenopausal. Patients whose ultrasound (USG), magnetic resonance, and mammographic (MMG) images available in our hospital, high-density masses were detected in the MMG with irregular (77%), microlobulated (80%) and spiculated margins (63%), unaccompanied by asymmetry and structural distortion. Calcifications were less common than invasive breast cancer, present only in four patients (17%). When NEBC were compared to ductal carcinomas (n=925), NEBC were more often human epidermal growth factor receptor 2 negative (p=0.039), estrogen receptor positive (p=0.05), progesterone receptor positive (0.03), and the NEBC patients were older (p=0.02). Age, grade, metastatic status, lymph node number, and molecular type were identified as prognostic factors that significantly affect survival in both groups (p<0.05). CONCLUSION: NEBC is a subtype that is both histopathologically and radiologically distinct from other breast cancer subtypes, and neuroendocrine differentiation may be an important predictive marker in the future. Med Bull Sisli Etfal Hosp 2021-12-29 /pmc/articles/PMC8907703/ /pubmed/35317367 http://dx.doi.org/10.14744/SEMB.2021.66503 Text en Copyright © by The Medical Bulletin of Sisli Etfal Hospital https://creativecommons.org/licenses/by/3.0/This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
spellingShingle Original Research
Ozdemir, Ozlem
Zengel, Baha
Yildiz, Yasar
Saray, Seray
Alacacioglu, Ahmet
Tasli, Funda
Can Erdi, Zuleyha
Oflazoglu, Utku
Taskaynatan, Halil
Salman, Tarik
Varol, Umut
Hilal Adibelli, Zehra
Durusoy, Raika
Kucukzeybek, Yuksel
Neuroendocrine Differentiated Breast Cancer Cases: A Retrospective Analysis and Literature Review
title Neuroendocrine Differentiated Breast Cancer Cases: A Retrospective Analysis and Literature Review
title_full Neuroendocrine Differentiated Breast Cancer Cases: A Retrospective Analysis and Literature Review
title_fullStr Neuroendocrine Differentiated Breast Cancer Cases: A Retrospective Analysis and Literature Review
title_full_unstemmed Neuroendocrine Differentiated Breast Cancer Cases: A Retrospective Analysis and Literature Review
title_short Neuroendocrine Differentiated Breast Cancer Cases: A Retrospective Analysis and Literature Review
title_sort neuroendocrine differentiated breast cancer cases: a retrospective analysis and literature review
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907703/
https://www.ncbi.nlm.nih.gov/pubmed/35317367
http://dx.doi.org/10.14744/SEMB.2021.66503
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