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Allergic Bronchopulmonary Mycosis Caused by Mucor Overlapping With Invasive Pulmonary Mucormycosis: A Case Report

Mucormycosis is a rare and invasive fungal infection with high mortality. Cases of invasive pulmonary mucormycosis that involve allergic reactions such as allergic bronchopulmonary mycosis are rarely reported. Herein, we describe a case of invasive pulmonary mucormycosis overlapping with allergic di...

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Autores principales: Zhang, Ruhui, Jin, Ge, Zhan, Yasheng, Shen, Lisha, Yao, Yake, Gao, Qiqi, Yang, Qing, Zhou, Jianying, Zhou, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907707/
https://www.ncbi.nlm.nih.gov/pubmed/35280885
http://dx.doi.org/10.3389/fmed.2022.831213
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author Zhang, Ruhui
Jin, Ge
Zhan, Yasheng
Shen, Lisha
Yao, Yake
Gao, Qiqi
Yang, Qing
Zhou, Jianying
Zhou, Hua
author_facet Zhang, Ruhui
Jin, Ge
Zhan, Yasheng
Shen, Lisha
Yao, Yake
Gao, Qiqi
Yang, Qing
Zhou, Jianying
Zhou, Hua
author_sort Zhang, Ruhui
collection PubMed
description Mucormycosis is a rare and invasive fungal infection with high mortality. Cases of invasive pulmonary mucormycosis that involve allergic reactions such as allergic bronchopulmonary mycosis are rarely reported. Herein, we describe a case of invasive pulmonary mucormycosis overlapping with allergic diseases in a patient who presented with eosinophilia and high total plasma immunoglobulin E (IgE). The patient was successfully treated with systemic corticosteroids (initial dose of prednisolone approximately 0.5 mg/kg per day, total duration less than 3 months) combined with posaconazole antifungal therapy. The treatment resulted in recovery of peripheral-blood eosinophil count and total plasma IgE, and significant reduction in lung lesions. A subsequent lobectomy was performed. The findings in this case indicate that systemic corticosteroid therapy may contribute to the treatment of pulmonary mucormycosis combined with allergic factors.
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spelling pubmed-89077072022-03-11 Allergic Bronchopulmonary Mycosis Caused by Mucor Overlapping With Invasive Pulmonary Mucormycosis: A Case Report Zhang, Ruhui Jin, Ge Zhan, Yasheng Shen, Lisha Yao, Yake Gao, Qiqi Yang, Qing Zhou, Jianying Zhou, Hua Front Med (Lausanne) Medicine Mucormycosis is a rare and invasive fungal infection with high mortality. Cases of invasive pulmonary mucormycosis that involve allergic reactions such as allergic bronchopulmonary mycosis are rarely reported. Herein, we describe a case of invasive pulmonary mucormycosis overlapping with allergic diseases in a patient who presented with eosinophilia and high total plasma immunoglobulin E (IgE). The patient was successfully treated with systemic corticosteroids (initial dose of prednisolone approximately 0.5 mg/kg per day, total duration less than 3 months) combined with posaconazole antifungal therapy. The treatment resulted in recovery of peripheral-blood eosinophil count and total plasma IgE, and significant reduction in lung lesions. A subsequent lobectomy was performed. The findings in this case indicate that systemic corticosteroid therapy may contribute to the treatment of pulmonary mucormycosis combined with allergic factors. Frontiers Media S.A. 2022-02-24 /pmc/articles/PMC8907707/ /pubmed/35280885 http://dx.doi.org/10.3389/fmed.2022.831213 Text en Copyright © 2022 Zhang, Jin, Zhan, Shen, Yao, Gao, Yang, Zhou and Zhou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Zhang, Ruhui
Jin, Ge
Zhan, Yasheng
Shen, Lisha
Yao, Yake
Gao, Qiqi
Yang, Qing
Zhou, Jianying
Zhou, Hua
Allergic Bronchopulmonary Mycosis Caused by Mucor Overlapping With Invasive Pulmonary Mucormycosis: A Case Report
title Allergic Bronchopulmonary Mycosis Caused by Mucor Overlapping With Invasive Pulmonary Mucormycosis: A Case Report
title_full Allergic Bronchopulmonary Mycosis Caused by Mucor Overlapping With Invasive Pulmonary Mucormycosis: A Case Report
title_fullStr Allergic Bronchopulmonary Mycosis Caused by Mucor Overlapping With Invasive Pulmonary Mucormycosis: A Case Report
title_full_unstemmed Allergic Bronchopulmonary Mycosis Caused by Mucor Overlapping With Invasive Pulmonary Mucormycosis: A Case Report
title_short Allergic Bronchopulmonary Mycosis Caused by Mucor Overlapping With Invasive Pulmonary Mucormycosis: A Case Report
title_sort allergic bronchopulmonary mycosis caused by mucor overlapping with invasive pulmonary mucormycosis: a case report
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907707/
https://www.ncbi.nlm.nih.gov/pubmed/35280885
http://dx.doi.org/10.3389/fmed.2022.831213
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