An Autopsy Case of Disseminated Varicella Zoster Virus Infection during the Treatment of Nephrotic Syndrome

A 68-year-old woman developed systemic blisters while receiving treatment for nephrotic syndrome. As she also developed marked liver dysfunction and disseminated intravascular coagulation, she was admitted to our hospital. She was diagnosed with varicella zoster virus (VZV) infection. Treatment was...

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Detalles Bibliográficos
Autores principales: Kuwano, Katsuhisa, Ota, Yuki, Tsuji, Kiyokazu, Torigoe, Kenta, Yamashita, Ayuko, Muta, Kumiko, Kitamura, Mineaki, Yamashita, Hiroshi, Uramatsu, Tadashi, Tashiro, Masato, Hayashi, Hiroko, Izumikawa, Koichi, Mukae, Hiroshi, Nishino, Tomoya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907779/
https://www.ncbi.nlm.nih.gov/pubmed/34393162
http://dx.doi.org/10.2169/internalmedicine.7332-21
Descripción
Sumario:A 68-year-old woman developed systemic blisters while receiving treatment for nephrotic syndrome. As she also developed marked liver dysfunction and disseminated intravascular coagulation, she was admitted to our hospital. She was diagnosed with varicella zoster virus (VZV) infection. Treatment was administered in the intensive-care unit, but the patient died on day 24 post-admission after severe VZV infection. A post-mortem examination showed micro-abscesses and necrosis caused by varicella zoster infection in multiple organs, including the liver, kidneys, and gastrointestinal tract. Because VZV infection can become severe in immunocompromised patients, careful consideration is needed for the prevention and treatment of the viral infection.

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