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Kynurenines in the Pathogenesis of Peripheral Neuropathy During Leprosy and COVID-19

Inflammatory disorders are associated with the activation of tryptophan (TRYP) catabolism via the kynurenine pathway (KP). Several reports have demonstrated the role of KP in the immunopathophysiology of both leprosy and coronavirus disease 19 (COVID-19). The nervous system can be affected in infect...

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Autores principales: de Oliveira, Jéssica Araujo da Paixão, de Athaide, Mariana Martins, Rahman, Atta Ur, de Mattos Barbosa, Mayara Garcia, Jardim, Marcia Maria, Moraes, Milton Ozório, Pinheiro, Roberta Olmo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907883/
https://www.ncbi.nlm.nih.gov/pubmed/35281455
http://dx.doi.org/10.3389/fcimb.2022.815738
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author de Oliveira, Jéssica Araujo da Paixão
de Athaide, Mariana Martins
Rahman, Atta Ur
de Mattos Barbosa, Mayara Garcia
Jardim, Marcia Maria
Moraes, Milton Ozório
Pinheiro, Roberta Olmo
author_facet de Oliveira, Jéssica Araujo da Paixão
de Athaide, Mariana Martins
Rahman, Atta Ur
de Mattos Barbosa, Mayara Garcia
Jardim, Marcia Maria
Moraes, Milton Ozório
Pinheiro, Roberta Olmo
author_sort de Oliveira, Jéssica Araujo da Paixão
collection PubMed
description Inflammatory disorders are associated with the activation of tryptophan (TRYP) catabolism via the kynurenine pathway (KP). Several reports have demonstrated the role of KP in the immunopathophysiology of both leprosy and coronavirus disease 19 (COVID-19). The nervous system can be affected in infections caused by both Mycobacterium leprae and SARS-CoV-2, but the mechanisms involved in the peripheral neural damage induced by these infectious agents are not fully understood. In recent years KP has received greater attention due the importance of kynurenine metabolites in infectious diseases, immune dysfunction and nervous system disorders. In this review, we discuss how modulation of the KP may aid in controlling the damage to peripheral nerves and the effects of KP activation on neural damage during leprosy or COVID-19 individually and we speculate its role during co-infection.
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spelling pubmed-89078832022-03-11 Kynurenines in the Pathogenesis of Peripheral Neuropathy During Leprosy and COVID-19 de Oliveira, Jéssica Araujo da Paixão de Athaide, Mariana Martins Rahman, Atta Ur de Mattos Barbosa, Mayara Garcia Jardim, Marcia Maria Moraes, Milton Ozório Pinheiro, Roberta Olmo Front Cell Infect Microbiol Cellular and Infection Microbiology Inflammatory disorders are associated with the activation of tryptophan (TRYP) catabolism via the kynurenine pathway (KP). Several reports have demonstrated the role of KP in the immunopathophysiology of both leprosy and coronavirus disease 19 (COVID-19). The nervous system can be affected in infections caused by both Mycobacterium leprae and SARS-CoV-2, but the mechanisms involved in the peripheral neural damage induced by these infectious agents are not fully understood. In recent years KP has received greater attention due the importance of kynurenine metabolites in infectious diseases, immune dysfunction and nervous system disorders. In this review, we discuss how modulation of the KP may aid in controlling the damage to peripheral nerves and the effects of KP activation on neural damage during leprosy or COVID-19 individually and we speculate its role during co-infection. Frontiers Media S.A. 2022-02-24 /pmc/articles/PMC8907883/ /pubmed/35281455 http://dx.doi.org/10.3389/fcimb.2022.815738 Text en Copyright © 2022 Oliveira, Athaide, Rahman, de Mattos Barbosa, Jardim, Moraes and Pinheiro https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
de Oliveira, Jéssica Araujo da Paixão
de Athaide, Mariana Martins
Rahman, Atta Ur
de Mattos Barbosa, Mayara Garcia
Jardim, Marcia Maria
Moraes, Milton Ozório
Pinheiro, Roberta Olmo
Kynurenines in the Pathogenesis of Peripheral Neuropathy During Leprosy and COVID-19
title Kynurenines in the Pathogenesis of Peripheral Neuropathy During Leprosy and COVID-19
title_full Kynurenines in the Pathogenesis of Peripheral Neuropathy During Leprosy and COVID-19
title_fullStr Kynurenines in the Pathogenesis of Peripheral Neuropathy During Leprosy and COVID-19
title_full_unstemmed Kynurenines in the Pathogenesis of Peripheral Neuropathy During Leprosy and COVID-19
title_short Kynurenines in the Pathogenesis of Peripheral Neuropathy During Leprosy and COVID-19
title_sort kynurenines in the pathogenesis of peripheral neuropathy during leprosy and covid-19
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907883/
https://www.ncbi.nlm.nih.gov/pubmed/35281455
http://dx.doi.org/10.3389/fcimb.2022.815738
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