Macrophages: shapes and functions

Macrophages are cells of the innate immune system and represent an important component of the first-line defense against pathogens and tumor cells. Here, their diverse functions in inflammation and tumor defense are described, and the mechanisms, tools, and activation pathways and states applied are...

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Detalles Bibliográficos
Autores principales: Lendeckel, Uwe, Venz, Simone, Wolke, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Lecture Text
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907910/
https://www.ncbi.nlm.nih.gov/pubmed/35287314
http://dx.doi.org/10.1007/s40828-022-00163-4
Descripción
Sumario:Macrophages are cells of the innate immune system and represent an important component of the first-line defense against pathogens and tumor cells. Here, their diverse functions in inflammation and tumor defense are described, and the mechanisms, tools, and activation pathways and states applied are presented. The main focus is on the role and origin of reactive oxygen species (ROS), the important signal pathways TLR/NF-κB, and the M1/​​M2 polarization of macrophages. GRAPHICAL ABSTRACT: [Image: see text]

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