Macrophages: shapes and functions

Macrophages are cells of the innate immune system and represent an important component of the first-line defense against pathogens and tumor cells. Here, their diverse functions in inflammation and tumor defense are described, and the mechanisms, tools, and activation pathways and states applied are...

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Detalles Bibliográficos
Autores principales: Lendeckel, Uwe, Venz, Simone, Wolke, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Lecture Text
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907910/
https://www.ncbi.nlm.nih.gov/pubmed/35287314
http://dx.doi.org/10.1007/s40828-022-00163-4
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author Lendeckel, Uwe
Venz, Simone
Wolke, Carmen
author_facet Lendeckel, Uwe
Venz, Simone
Wolke, Carmen
author_sort Lendeckel, Uwe
collection PubMed
description Macrophages are cells of the innate immune system and represent an important component of the first-line defense against pathogens and tumor cells. Here, their diverse functions in inflammation and tumor defense are described, and the mechanisms, tools, and activation pathways and states applied are presented. The main focus is on the role and origin of reactive oxygen species (ROS), the important signal pathways TLR/NF-κB, and the M1/​​M2 polarization of macrophages. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-89079102022-03-10 Macrophages: shapes and functions Lendeckel, Uwe Venz, Simone Wolke, Carmen ChemTexts Lecture Text Macrophages are cells of the innate immune system and represent an important component of the first-line defense against pathogens and tumor cells. Here, their diverse functions in inflammation and tumor defense are described, and the mechanisms, tools, and activation pathways and states applied are presented. The main focus is on the role and origin of reactive oxygen species (ROS), the important signal pathways TLR/NF-κB, and the M1/​​M2 polarization of macrophages. GRAPHICAL ABSTRACT: [Image: see text] Springer International Publishing 2022-03-10 2022 /pmc/articles/PMC8907910/ /pubmed/35287314 http://dx.doi.org/10.1007/s40828-022-00163-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Lecture Text
Lendeckel, Uwe
Venz, Simone
Wolke, Carmen
Macrophages: shapes and functions
title Macrophages: shapes and functions
title_full Macrophages: shapes and functions
title_fullStr Macrophages: shapes and functions
title_full_unstemmed Macrophages: shapes and functions
title_short Macrophages: shapes and functions
title_sort macrophages: shapes and functions
topic Lecture Text
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907910/
https://www.ncbi.nlm.nih.gov/pubmed/35287314
http://dx.doi.org/10.1007/s40828-022-00163-4
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