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MORPHOLOGICAL TRAITS OF HEPATIC PARENCHYMAL TISSUE REPAIR FOLLOWING EXPERIMENTAL INJURY

The aim of the study was to investigate morphological traits of hepatic parenchymal tissue repair in response to injury using the conventional technique (closure) and an innovation method (such as hemostatic medication swab packing and modified batching). The experimental study was carried out on la...

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Detalles Bibliográficos
Autores principales: Vorontsov, Aleksey K., Troshin, Vladislav P., Parkhisenko, Yuri A., Korsakov, Anton V., Klimashevich, Aleksandr V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sestre Milosrdnice University Hospital and Institute of Clinical Medical Research, Vinogradska cesta c. 29 Zagreb 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907961/
https://www.ncbi.nlm.nih.gov/pubmed/35282489
http://dx.doi.org/10.20471/acc.2021.60.03.18
Descripción
Sumario:The aim of the study was to investigate morphological traits of hepatic parenchymal tissue repair in response to injury using the conventional technique (closure) and an innovation method (such as hemostatic medication swab packing and modified batching). The experimental study was carried out on laboratory rats of the Winzar breed using light microscopy, standard stains for micropreparations, and morphometry. Histopathologic examination of micropreparations stained by standard methods revealed pronounced dystrophic processes in hepatocytes located near the necrotic zone (albuminous and hydropic degeneration and chromatin fragmentation in the nuclei). Morphometric studies showed a significant decrease (p<0.001) in almost all indicators of the size of cells and nuclei both near necrosis and distant from it on day 28 of the experiment in the experimental group in comparison to the control group. The results obtained pointed to more intense repair processes when applying the innovation method.