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Predictive value of frailty in the mortality of hospitalized patients with COVID-19: a systematic review and meta-analysis

BACKGROUND: The present study aimed to analyze the impact of frailty on mortality risk among hospitalized patients with coronavirus disease 2019 (COVID-19). METHODS: Literature searches were conducted using the MEDLINE, Embase, and Cochrane databases for articles reporting the association between fr...

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Autores principales: Zou, Yupei, Han, Maonan, Wang, Jiarong, Zhao, Jichun, Gan, Huatian, Yang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908186/
https://www.ncbi.nlm.nih.gov/pubmed/35280387
http://dx.doi.org/10.21037/atm-22-274
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author Zou, Yupei
Han, Maonan
Wang, Jiarong
Zhao, Jichun
Gan, Huatian
Yang, Yi
author_facet Zou, Yupei
Han, Maonan
Wang, Jiarong
Zhao, Jichun
Gan, Huatian
Yang, Yi
author_sort Zou, Yupei
collection PubMed
description BACKGROUND: The present study aimed to analyze the impact of frailty on mortality risk among hospitalized patients with coronavirus disease 2019 (COVID-19). METHODS: Literature searches were conducted using the MEDLINE, Embase, and Cochrane databases for articles reporting the association between frailty and mortality in hospitalized patients with COVID-19. The quality of the included studies was assessed using the Newcastle-Ottawa scale (NOS). A random-effects meta-analysis was performed to calculate the pooled effects. RESULTS: A total of 21 studies with 26,652 hospitalized patients were included. Sixteen studies used the Clinical Frailty Score (CFS), and five used other frailty assessment tools. The pooled estimates of frailty in hospitalized patients with COVID-19 were 51.4% [95% confidence interval (CI): 39.9–62.9%]. In the CFS group, frail patients experienced a higher rate of short-term mortality than non-frail patients [odds ratio (OR) =3.0; 95% CI: 2.3–3.9; I(2)=72.7%; P<0.001]. In the other tools group, frail patients had a significantly increased short-term mortality risk compared with non-frail patients (OR =2.4; 95% CI: 1.4–4.1; P=0.001). Overall, a higher short-term mortality risk was observed for frail patients than non-frail patients (OR =2.8; 95% CI: 2.3–3.5; P<0.001). In older adults, frail patients had a higher rate of short-term mortality than non-frail patients (OR =2.3; 95% CI: 1.8–2.9; P<0.001). CONCLUSIONS: Compared to non-frail hospitalized patients with COVID-19, frail patients suffered a higher risk of all-cause mortality, and this result was also found in the older adult group.
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spelling pubmed-89081862022-03-11 Predictive value of frailty in the mortality of hospitalized patients with COVID-19: a systematic review and meta-analysis Zou, Yupei Han, Maonan Wang, Jiarong Zhao, Jichun Gan, Huatian Yang, Yi Ann Transl Med Original Article BACKGROUND: The present study aimed to analyze the impact of frailty on mortality risk among hospitalized patients with coronavirus disease 2019 (COVID-19). METHODS: Literature searches were conducted using the MEDLINE, Embase, and Cochrane databases for articles reporting the association between frailty and mortality in hospitalized patients with COVID-19. The quality of the included studies was assessed using the Newcastle-Ottawa scale (NOS). A random-effects meta-analysis was performed to calculate the pooled effects. RESULTS: A total of 21 studies with 26,652 hospitalized patients were included. Sixteen studies used the Clinical Frailty Score (CFS), and five used other frailty assessment tools. The pooled estimates of frailty in hospitalized patients with COVID-19 were 51.4% [95% confidence interval (CI): 39.9–62.9%]. In the CFS group, frail patients experienced a higher rate of short-term mortality than non-frail patients [odds ratio (OR) =3.0; 95% CI: 2.3–3.9; I(2)=72.7%; P<0.001]. In the other tools group, frail patients had a significantly increased short-term mortality risk compared with non-frail patients (OR =2.4; 95% CI: 1.4–4.1; P=0.001). Overall, a higher short-term mortality risk was observed for frail patients than non-frail patients (OR =2.8; 95% CI: 2.3–3.5; P<0.001). In older adults, frail patients had a higher rate of short-term mortality than non-frail patients (OR =2.3; 95% CI: 1.8–2.9; P<0.001). CONCLUSIONS: Compared to non-frail hospitalized patients with COVID-19, frail patients suffered a higher risk of all-cause mortality, and this result was also found in the older adult group. AME Publishing Company 2022-02 /pmc/articles/PMC8908186/ /pubmed/35280387 http://dx.doi.org/10.21037/atm-22-274 Text en 2022 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Zou, Yupei
Han, Maonan
Wang, Jiarong
Zhao, Jichun
Gan, Huatian
Yang, Yi
Predictive value of frailty in the mortality of hospitalized patients with COVID-19: a systematic review and meta-analysis
title Predictive value of frailty in the mortality of hospitalized patients with COVID-19: a systematic review and meta-analysis
title_full Predictive value of frailty in the mortality of hospitalized patients with COVID-19: a systematic review and meta-analysis
title_fullStr Predictive value of frailty in the mortality of hospitalized patients with COVID-19: a systematic review and meta-analysis
title_full_unstemmed Predictive value of frailty in the mortality of hospitalized patients with COVID-19: a systematic review and meta-analysis
title_short Predictive value of frailty in the mortality of hospitalized patients with COVID-19: a systematic review and meta-analysis
title_sort predictive value of frailty in the mortality of hospitalized patients with covid-19: a systematic review and meta-analysis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908186/
https://www.ncbi.nlm.nih.gov/pubmed/35280387
http://dx.doi.org/10.21037/atm-22-274
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