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Inhibition of endothelial Nox2 activation by LMH001 protects mice from angiotensin II-induced vascular oxidative stress, hypertension and aortic aneurysm

Endothelial oxidative stress and inflammation attributable to the activation of a Nox2-NADPH oxidase are key features of many cardiovascular diseases. Here, we report a novel small chemical compound (LMH001, MW = 290.079), by blocking phosphorylated p47(phox) interaction with p22(phox), inhibited ef...

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Detalles Bibliográficos
Autores principales:	Fan, Lampson M., Liu, Fangfei, Du, Junjie, Geng, Li, Li, Jian-Mei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908273/ https://www.ncbi.nlm.nih.gov/pubmed/35276443 http://dx.doi.org/10.1016/j.redox.2022.102269

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