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Sex-based differences in histology, staging, and prognosis among 2983 gastric cancer surgery patients

BACKGROUND: Few studies have been conducted on sex differences in the incidence, pathophysiology, and prognosis of gastric cancer (GC). AIM: To analyze the differences in GC characteristics according to sex in patients who underwent surgical treatment for GC. METHODS: A total of 2983 patients diagno...

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Autores principales: Choi, Yonghoon, Kim, Nayoung, Kim, Ki Wook, Jo, Hyeong Ho, Park, Jaehyung, Yoon, Hyuk, Shin, Cheol Min, Park, Young Soo, Lee, Dong Ho, Oh, Hyeon Jeong, Lee, Hye Seung, Park, Young Suk, Ahn, Sang-Hoon, Suh, Yun-Suhk, Park, Do Joong, Kim, Hyung-Ho, Kim, Ji-Won, Kim, Jin Won, Lee, Keun-Wook, Chang, Won, Park, Ji Hoon, Lee, Yoon Jin, Lee, Kyoung Ho, Kim, Young Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908285/
https://www.ncbi.nlm.nih.gov/pubmed/35317055
http://dx.doi.org/10.3748/wjg.v28.i9.933
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author Choi, Yonghoon
Kim, Nayoung
Kim, Ki Wook
Jo, Hyeong Ho
Park, Jaehyung
Yoon, Hyuk
Shin, Cheol Min
Park, Young Soo
Lee, Dong Ho
Oh, Hyeon Jeong
Lee, Hye Seung
Park, Young Suk
Ahn, Sang-Hoon
Suh, Yun-Suhk
Park, Do Joong
Kim, Hyung-Ho
Kim, Ji-Won
Kim, Jin Won
Lee, Keun-Wook
Chang, Won
Park, Ji Hoon
Lee, Yoon Jin
Lee, Kyoung Ho
Kim, Young Hoon
author_facet Choi, Yonghoon
Kim, Nayoung
Kim, Ki Wook
Jo, Hyeong Ho
Park, Jaehyung
Yoon, Hyuk
Shin, Cheol Min
Park, Young Soo
Lee, Dong Ho
Oh, Hyeon Jeong
Lee, Hye Seung
Park, Young Suk
Ahn, Sang-Hoon
Suh, Yun-Suhk
Park, Do Joong
Kim, Hyung-Ho
Kim, Ji-Won
Kim, Jin Won
Lee, Keun-Wook
Chang, Won
Park, Ji Hoon
Lee, Yoon Jin
Lee, Kyoung Ho
Kim, Young Hoon
author_sort Choi, Yonghoon
collection PubMed
description BACKGROUND: Few studies have been conducted on sex differences in the incidence, pathophysiology, and prognosis of gastric cancer (GC). AIM: To analyze the differences in GC characteristics according to sex in patients who underwent surgical treatment for GC. METHODS: A total of 2983 patients diagnosed with gastric adenocarcinoma who received surgical treatment at the Seoul National University Bundang Hospital between 2003 and 2017 were included. Baseline clinicopathological characteristics, histologic type of GC, overall and GC-specific survival rates, and associated risk factors were analyzed. RESULTS: Among the 2983 patients, 2005 (67.2%) and 978 (32.8%) were males and females, respectively. The average age of the female group (59.36 years) was significantly younger than that of the male group (61.66 years; P < 0.001). Cancer of the gastric body (P < 0.001) and diffuse-type histology (P < 0.001) were more common in females than in males. This trend was more prominent in females younger than 60 years of age, with a significantly higher proportion of diffuse-type cancer than in the male group. Regardless of sex, diffuse-type GC was more common in younger patients, and the proportion of intestinal-type GC increased with age. The overall survival rate was significantly higher in females (P < 0.001). However, this difference disappeared for GC-specific survival (P = 0.168), except for the poor GC-specific survival rate in advanced-stage cancer (stage III or above) in females (P = 0.045). The risk factors for GC-related mortality were older age, upper location of GC, and diffuse- or mixed-type histology. In terms of comorbidities, more males died from diseases other than GC, including other malignancies such as lung cancer, hepatocellular carcinoma, and pancreatic cancer, and respiratory diseases such as interstitial lung disease and chronic obstructive pulmonary disease, while there were relatively more cardiovascular or cerebrovascular deaths in females. CONCLUSION: Sex-based differences in GC were observed in clinicopathological features, including age at diagnosis, tumor location, histologic type, survival rate, and comorbidities.
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spelling pubmed-89082852022-03-21 Sex-based differences in histology, staging, and prognosis among 2983 gastric cancer surgery patients Choi, Yonghoon Kim, Nayoung Kim, Ki Wook Jo, Hyeong Ho Park, Jaehyung Yoon, Hyuk Shin, Cheol Min Park, Young Soo Lee, Dong Ho Oh, Hyeon Jeong Lee, Hye Seung Park, Young Suk Ahn, Sang-Hoon Suh, Yun-Suhk Park, Do Joong Kim, Hyung-Ho Kim, Ji-Won Kim, Jin Won Lee, Keun-Wook Chang, Won Park, Ji Hoon Lee, Yoon Jin Lee, Kyoung Ho Kim, Young Hoon World J Gastroenterol Retrospective Cohort Study BACKGROUND: Few studies have been conducted on sex differences in the incidence, pathophysiology, and prognosis of gastric cancer (GC). AIM: To analyze the differences in GC characteristics according to sex in patients who underwent surgical treatment for GC. METHODS: A total of 2983 patients diagnosed with gastric adenocarcinoma who received surgical treatment at the Seoul National University Bundang Hospital between 2003 and 2017 were included. Baseline clinicopathological characteristics, histologic type of GC, overall and GC-specific survival rates, and associated risk factors were analyzed. RESULTS: Among the 2983 patients, 2005 (67.2%) and 978 (32.8%) were males and females, respectively. The average age of the female group (59.36 years) was significantly younger than that of the male group (61.66 years; P < 0.001). Cancer of the gastric body (P < 0.001) and diffuse-type histology (P < 0.001) were more common in females than in males. This trend was more prominent in females younger than 60 years of age, with a significantly higher proportion of diffuse-type cancer than in the male group. Regardless of sex, diffuse-type GC was more common in younger patients, and the proportion of intestinal-type GC increased with age. The overall survival rate was significantly higher in females (P < 0.001). However, this difference disappeared for GC-specific survival (P = 0.168), except for the poor GC-specific survival rate in advanced-stage cancer (stage III or above) in females (P = 0.045). The risk factors for GC-related mortality were older age, upper location of GC, and diffuse- or mixed-type histology. In terms of comorbidities, more males died from diseases other than GC, including other malignancies such as lung cancer, hepatocellular carcinoma, and pancreatic cancer, and respiratory diseases such as interstitial lung disease and chronic obstructive pulmonary disease, while there were relatively more cardiovascular or cerebrovascular deaths in females. CONCLUSION: Sex-based differences in GC were observed in clinicopathological features, including age at diagnosis, tumor location, histologic type, survival rate, and comorbidities. Baishideng Publishing Group Inc 2022-03-07 2022-03-07 /pmc/articles/PMC8908285/ /pubmed/35317055 http://dx.doi.org/10.3748/wjg.v28.i9.933 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Retrospective Cohort Study
Choi, Yonghoon
Kim, Nayoung
Kim, Ki Wook
Jo, Hyeong Ho
Park, Jaehyung
Yoon, Hyuk
Shin, Cheol Min
Park, Young Soo
Lee, Dong Ho
Oh, Hyeon Jeong
Lee, Hye Seung
Park, Young Suk
Ahn, Sang-Hoon
Suh, Yun-Suhk
Park, Do Joong
Kim, Hyung-Ho
Kim, Ji-Won
Kim, Jin Won
Lee, Keun-Wook
Chang, Won
Park, Ji Hoon
Lee, Yoon Jin
Lee, Kyoung Ho
Kim, Young Hoon
Sex-based differences in histology, staging, and prognosis among 2983 gastric cancer surgery patients
title Sex-based differences in histology, staging, and prognosis among 2983 gastric cancer surgery patients
title_full Sex-based differences in histology, staging, and prognosis among 2983 gastric cancer surgery patients
title_fullStr Sex-based differences in histology, staging, and prognosis among 2983 gastric cancer surgery patients
title_full_unstemmed Sex-based differences in histology, staging, and prognosis among 2983 gastric cancer surgery patients
title_short Sex-based differences in histology, staging, and prognosis among 2983 gastric cancer surgery patients
title_sort sex-based differences in histology, staging, and prognosis among 2983 gastric cancer surgery patients
topic Retrospective Cohort Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8908285/
https://www.ncbi.nlm.nih.gov/pubmed/35317055
http://dx.doi.org/10.3748/wjg.v28.i9.933
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